Spyre Therapeutics (SYRE) Stock Price

Spyre Therapeutics Price

NASDAQ·CLOSED
89.26
​
Market closed

Revenue at Spyre Therapeutics has contracted by 19.3% per year over the past 9 years to 886,000.00 USD. For Spyre Therapeutics, the net margin of -23,478.3% is down versus -1,140.6% a few years ago. The consensus 12-month price target for Spyre Therapeutics is 112.00 USD, about 25.5% above where the stock trades today. Of 22 analysts, 20 rate the stock a buy — an overall Buy consensus.

Spyre Therapeutics stock price

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Spyre Therapeutics business model & stock analysis

Spyre Therapeutics Inc generates revenue through the development and commercialization of biopharmaceutical products targeting inflammatory bowel disease. The company focuses on creating next-generation therapies using antibody engineering and precision medicine approaches. Its pipeline includes SPY001, a monoclonal antibody targeting α4β7 integrin, SPY002 targeting TL1A, and SPY003 targeting IL-23 p19 subunit. These product candidates are developed for patient selection based on precision medicine strategies. The company's revenue model relies on future product sales once regulatory approvals are obtained for its pipeline programs. The primary buyers of Spyre Therapeutics' products will be healthcare providers and hospitals specializing in gastroenterology and inflammatory conditions. These institutions purchase biologics for treating IBD patients, particularly those requiring targeted therapies. The company's focus on α4β7, TL1A, and IL-23 pathways positions its products for patients with moderate to severe inflammatory bowel disease who may not respond to existing treatments. Spyre Therapeutics operates in the biotechnology sector with a specific focus on inflammatory bowel disease therapeutics. Its advanced product candidate SPY001 is designed as a highly potent, selective, and fully humanized monoclonal antibody. The company's revenue streams will emerge after successful clinical trials and regulatory approvals for its pipeline programs including SPY001, SPY002, SPY003, SPY004, SPY120, SPY130, and SPY230.

Frequently asked questions about Spyre Therapeutics

Analysts currently set an average price target of 105.36 USD for the Spyre Therapeutics stock (median: 112.00 USD), implying +18.0 % versus the latest price. The consensus is based on 22 analyst ratings.

22 analysts currently rate the Spyre Therapeutics stock: 20 recommend buying, 2 holding and 0 selling. For 2026, analysts expect Spyre Therapeutics to generate revenue of 88,600.00 USD and earnings per share of -2.32 USD.

Converted at the current exchange rate, the Spyre Therapeutics share trades at 79.68 EUR (89.26 USD).

The Spyre Therapeutics share (SYRE) is listed on 1 stock exchanges, including: NASDAQ (AGLE).

The expected revenue of Spyre Therapeutics is 88,600.00 USD. This figure is based on current financial data and reflects the company's business performance.

The expected profit of Spyre Therapeutics is -174.42 M USD. The net profit reflects the company's profitability after deducting all expenses.

The price-to-earnings ratio (P/E) of Spyre Therapeutics is currently -38.43. The P/E ratio compares the current share price to the earnings per share and helps investors assess the valuation of the Spyre Therapeutics stock.

The price-to-sales ratio (P/S) of Spyre Therapeutics is currently 75,652.49. The P/S ratio compares the market capitalization to the annual revenue and serves as a valuation metric for the Spyre Therapeutics stock.

The Eulerpool Quality Score for Spyre Therapeutics is 2/10.

The ISIN of Spyre Therapeutics is US00773J2024. The ISIN (International Securities Identification Number) is a globally unique identifier for securities.

The ticker of Spyre Therapeutics is SYRE. The ticker symbol is used to trade Spyre Therapeutics shares on the stock exchange.

Fair ValueTerminal
77.66 USD
Over-/UndervaluationTerminal
Fairly valued
Sector
Industry
Biotechnology
Number of shares
Employees
Revenue growth Ø5 years
EBIT growth Ø5 years
Net Income growth Ø5 years
Website spyre.com
Currency
USD
Initial public offering
Apr 7, 2016
ISIN
US00773J2024
Cusip
00773J202
Market capitalization
5.72 B USDMid Cap
52-Week Range
PEG
-4.83
P/E ratio
P/Ee 2026
-38.43
P/Ee 2027
-29.10
P/Ee 2028
-25.11
P/Ee 2029
-23.53
P/Ee 2030
-25.04
P/Se
75,652.49
EV/EBIT
—
P/B Ratio
7.99
ROE (Return on Equity)
ROA (Return on Assets)
ROCE (Return on Capital Employed)
ROIC (Return on Invested Capital)
-21.70 %
Last updated Oct 25, 2026, 5:04 PM

Spyre Therapeutics Peer Group

Spyre Therapeutics Ticker

NASDAQ · AGLE

Spyre Therapeutics FIGI

SYRE:US · BBG0067L94B2SYRE:UA · BBG009DXJ565SYRE:UC · BBG009DXJ574SYRE:UN · BBG009DXJ592SYRE:UP · BBG009DXJ5B9SYRE:UB · BBG009DXJ5D7SYRE:UM · BBG009DXJ5G4SYRE:UX · BBG009DXJ5H3SYRE:UR · BBG009DXJ5J1SYRE:UD · BBG009DXJ5N6SYRE:UF · BBG009DXJ5R2SYRE:VY · BBG009DXJ5S1