| 10,97756 % | ARK Investment Management LLC | 13.892.103 | 1.046.390 | |
| 10,48940 % | The Vanguard Group, Inc. | 13.274.332 | 858.134 | |
| 6,04078 % | Fidelity Management & Research Company LLC | 7.644.611 | -930.784 | |
| 5,99084 % | BlackRock Institutional Trust Company, N.A. | 7.581.405 | 2.173.050 | |
| 4,25225 % | Sumitomo Mitsui Trust Bank, Limited | 5.381.219 | -636.744 | |
| 3,26970 % | AQR Capital Management, LLC | 4.137.801 | 2.925.372 | |
| 2,29661 % | BofA Global Research (US) | 2.906.359 | 350.993 | |
| 2,27880 % | Millennium Management LLC | 2.883.827 | -2.649.791 | |
| 2,24446 % | Two Sigma Investments, LP | 2.840.361 | -329.644 | |
| 2,09468 % | Geode Capital Management, L.L.C. | 2.650.819 | 773.203 | |
| 1,96972 % | State Street Investment Management (US) | 2.492.676 | 680.475 | |
| 1,89470 % | Jacobs Levy Equity Management, Inc. | 2.397.739 | 1.231.016 | |
| 1,76494 % | Quantinno Capital Management LP | 2.233.526 | 1.506.530 | |
| 1,66476 % | VR Management, L.L.C. | 2.106.757 | 0 | |
| 1,49449 % | Wellington Management Company, LLP | 1.891.273 | 1.891.273 | |
| 1,25163 % | Morgan Stanley & Co. LLC | 1.583.938 | 185.313 | |
| 1,20774 % | Trexquant Investment LP | 1.528.391 | 388.103 | |
| 1,20655 % | Voloridge Investment Management, LLC | 1.526.892 | -96.783 | |
| 1,16338 % | Renaissance Technologies LLC | 1.472.255 | 782.700 | |
| 1,14761 % | Capital World Investors | 1.452.300 | 0 | |
| 1,06819 % | Fidelity Institutional Asset Management | 1.351.793 | 34.049 | |
| 1,01135 % | Algert Global LLC | 1.279.868 | 826.581 | |
| 0,86979 % | Blue Water Life Science Advisors, LP. | 1.100.720 | 1.100.720 | |
| 0,83557 % | Saxonov (Serge Wilson) | 1.057.411 | -900 | |
| 0,82264 % | Jump Financial, LLC | 1.041.051 | 588.769 | |
| 0,77257 % | T. Rowe Price Investment Management, Inc. | 977.685 | 977.685 | |
| 0,76071 % | Barclays Bank PLC | 962.677 | 178.686 | |
| 0,74256 % | Parametric Portfolio Associates LLC | 939.707 | 528.283 | |
| 0,71781 % | UBS Financial Services, Inc. | 908.391 | 75.603 | |
| 0,71461 % | Charles Schwab Investment Management, Inc. | 904.337 | 255.927 | |
| 0,70589 % | Northern Trust Investments, Inc. | 893.300 | 423.436 | |
| 0,65556 % | Numeric Investors LLC | 829.610 | 687.773 | |
| 0,62230 % | Federated MDTA LLC | 787.522 | 684.659 | |
| 0,58970 % | D. E. Shaw & Co., L.P. | 746.266 | -1.235.997 | |
| 0,49240 % | Acadian Asset Management LLC | 623.138 | 216.733 | |
| 0,49133 % | Lancaster Investment Management LLP | 621.779 | 146.288 | |
| 0,48621 % | Vestmark Advisory Solutions, Inc | 615.294 | 321.894 | |
| 0,44062 % | BMO Capital Markets (US) | 557.605 | 557.605 | |
| 0,43723 % | Aperio Group, LLC | 553.316 | 266.485 | |
| 0,42462 % | IEQ Capital LLC | 537.362 | 252.064 | |
| 0,40755 % | Goldman Sachs Asset Management, L.P. | 515.753 | 345.318 | |
| 0,39501 % | PDT Partners, LLC | 499.890 | -159.150 | |
| 0,39325 % | BlackRock Financial Management, Inc. | 497.658 | -6.066 | |
| 0,38070 % | Sands Capital Ventures LLC | 481.770 | 0 | |
| 0,37683 % | Russell Investments Trust Company | 476.878 | 475.265 | |
| 0,37562 % | RA Capital Management, LP | 475.343 | -1.468.904 | |
| 0,36909 % | Boston Management and Research | 467.079 | 0 | |
| 0,35065 % | Columbia Threadneedle Investments (US) | 443.749 | 313.160 | |
| 0,31585 % | Marshall Wace LLP | 399.702 | -17.749 | |
| 0,29544 % | Franklin Advisers, Inc. | 373.882 | 311.036 | |
| 0,29206 % | Stuelpnagel (John R) | 369.607 | 15.357 | |
| 0,26895 % | BlackRock Investment Management, LLC | 340.358 | 303.592 | |
| 0,26608 % | Morgan Stanley Investment Management Inc. (US) | 336.727 | 40.956 | |
| 0,25966 % | Bank of Nova Scotia | 328.600 | 328.600 | |
| 0,25820 % | Bellevue Asset Management AG | 326.751 | 95.754 | |
| 0,24605 % | Macquarie Investment Management | 311.380 | 311.380 | |
| 0,23326 % | Capital Fund Management S.A. | 295.188 | 20.727 | |
| 0,22858 % | IQ EQ Fund Management (Ireland) Limited | 289.269 | 184.757 | |
| 0,22639 % | ING Bank N.V. | 286.500 | 94.700 | |
| 0,21992 % | BlackRock Asset Management Ireland Limited | 278.313 | 2.639 | |
| 0,19523 % | Amova Asset Management Americas, Inc | 247.068 | 247.068 | |
| 0,19349 % | Numerai Gp LLC | 244.857 | -37.301 | |
| 0,18654 % | Invenomic Capital Management LP | 236.064 | 236.064 | |
| 0,17766 % | Nuveen LLC | 224.829 | 27.577 | |
| 0,16187 % | Amundi Asset Management, SAS | 204.847 | -115.493 | |
| 0,16105 % | Susquehanna International Group, LLP | 203.809 | -763.942 | |
| 0,15978 % | Whitaker (Eric S) | 202.202 | 45.563 | |
| 0,15962 % | CPP Investment Board | 202.000 | -3.600 | |
| 0,15501 % | BNY Mellon Asset Management | 196.168 | 50.708 | |
| 0,15484 % | Citadel Advisors LLC | 195.944 | -868.322 | |
| 0,14983 % | Readystate Asset Management LP | 189.608 | 189.608 | |
| 0,14737 % | Schweizerische Nationalbank | 186.500 | 0 | |
| 0,14698 % | National Bank of Canada | 186.007 | 186.007 | |
| 0,14381 % | Mellon Investments Corporation | 181.993 | 51.778 | |
| 0,14244 % | Mammen (Mathai) | 180.259 | 8.649 | |
| 0,14214 % | BlackRock Investment Management (UK) Ltd. | 179.880 | 35.852 | |
| 0,13908 % | Voleon Capital Management LP | 176.007 | 78.856 | |
| 0,13771 % | UBS Asset Management (Switzerland) | 174.272 | -3.930.432 | |
| 0,13433 % | Harvard Management Company, Inc. | 170.000 | 0 | |
| 0,13293 % | Citi Investment Research (US) | 168.219 | 84.275 | |
| 0,13107 % | Principal Global Investors (Equity) | 165.868 | 12.374 | |
| 0,13081 % | Rhumbline Advisers Ltd. Partnership | 165.539 | 45.049 | |
| 0,12932 % | Exome Asset Management LLC | 163.658 | 163.658 | |
| 0,12887 % | Osaic Holdings, Inc. | 163.082 | -142.564 | |
| 0,12862 % | Savant Wealth Management | 162.771 | 132.719 | |
| 0,12363 % | Financial Consulate, Inc. | 156.457 | 156.457 | |
| 0,12318 % | Invesco Capital Management LLC | 155.888 | 16.393 | |
| 0,12272 % | BNP Paribas Securities Corp. North America | 155.299 | -498.499 | |
| 0,12048 % | T. Rowe Price Associates, Inc. | 152.473 | 0 | |
| 0,11478 % | Dimensional Fund Advisors, L.P. | 145.256 | 15.109 | |
| 0,11333 % | Fred Alger Management, LLC | 143.413 | 77.983 | |
| 0,11136 % | Summit Trail Advisors, LLC | 140.924 | 104.885 | |
| 0,10538 % | Cerity Partners LLC | 133.354 | -7.418 | |
| 0,10424 % | Mirae Asset Global Investments (USA) LLC | 131.921 | -20.442 | |
| 0,09997 % | AllianceBernstein L.P. | 126.507 | 90.988 | |
| 0,09941 % | Carson Wealth Management Group | 125.804 | -6.706 | |
| 0,09767 % | Arrowstreet Capital, Limited Partnership | 123.604 | 107.023 | |
| 0,09643 % | Engineers Gate Manager, L.P. | 122.036 | 122.036 | |
| 0,09372 % | T. Rowe Price International Ltd | 118.605 | 19.814 | |
| 0,09256 % | Managed Account Advisors LLC | 117.130 | 5.107 | |