| 11,23878 % | ARK Investment Management LLC | 13.017.876 | 6.861 | |
| 9,35076 % | The Vanguard Group, Inc. | 10.830.980 | 100.138 | |
| 6,94088 % | BlackRock Institutional Trust Company, N.A. | 8.039.627 | -367.465 | |
| 3,77242 % | Two Sigma Investments, LP | 4.369.591 | 394.369 | |
| 3,48725 % | State Street Investment Management (US) | 4.039.285 | -470.976 | |
| 3,19692 % | Regeneron Pharmaceuticals Inc | 3.702.995 | 0 | |
| 2,31000 % | Baker Bros. Advisors LP | 2.675.674 | 2.031.558 | |
| 2,25004 % | Geode Capital Management, L.L.C. | 2.606.222 | 126.049 | |
| 2,03303 % | Amova Asset Management Co., Ltd. | 2.354.856 | -316.409 | |
| 1,68789 % | Morgan Stanley Investment Management Inc. (US) | 1.955.087 | 783.720 | |
| 1,61125 % | Dimensional Fund Advisors, L.P. | 1.866.309 | -101.857 | |
| 1,41874 % | Goldman Sachs & Company, Inc. | 1.643.331 | -615.092 | |
| 1,34096 % | Voloridge Investment Management, LLC | 1.553.234 | 37.620 | |
| 1,34033 % | Contrarius Investment Management Ltd. | 1.552.508 | -468.532 | |
| 1,31274 % | Fidelity Management & Research Company LLC | 1.520.548 | -69.754 | |
| 1,13225 % | Balyasny Asset Management LP | 1.311.480 | -203.605 | |
| 1,09625 % | Morgan Stanley & Co. LLC | 1.269.783 | -790.777 | |
| 1,05246 % | Woodline Partners LP | 1.219.068 | 1.194.962 | |
| 0,98579 % | BlackRock Financial Management, Inc. | 1.141.842 | -65.686 | |
| 0,97326 % | Trexquant Investment LP | 1.127.331 | 522.635 | |
| 0,78876 % | Granahan Investment Management, LLC | 913.622 | 437.676 | |
| 0,77135 % | Leonard (John M) | 893.460 | 81.871 | |
| 0,73949 % | Charles Schwab Investment Management, Inc. | 856.549 | 76.325 | |
| 0,71744 % | Millennium Management LLC | 831.006 | 244.517 | |
| 0,71202 % | D. E. Shaw & Co., L.P. | 824.727 | 792.331 | |
| 0,69589 % | Northern Trust Investments, Inc. | 806.045 | -12.505 | |
| 0,67755 % | Stifel, Nicolaus & Company, Incorporated | 784.808 | -4.645 | |
| 0,65957 % | Susquehanna International Group, LLP | 763.981 | 334.876 | |
| 0,62973 % | Himension Capital (Singapore) Pte. Ltd | 729.421 | -23.255 | |
| 0,61295 % | Citadel Advisors LLC | 709.981 | -2.047.587 | |
| 0,58439 % | Renaissance Technologies LLC | 676.900 | 676.900 | |
| 0,56117 % | Armistice Capital LLC | 650.000 | 286.000 | |
| 0,55110 % | Vestmark Advisory Solutions, Inc | 638.342 | 326.460 | |
| 0,53838 % | Marex Group plc | 623.600 | 623.600 | |
| 0,51105 % | UBS Financial Services, Inc. | 591.949 | -259.703 | |
| 0,46311 % | Parametric Portfolio Associates LLC | 536.416 | 319.523 | |
| 0,44148 % | Barclays Bank PLC | 511.362 | 273.635 | |
| 0,41799 % | J.P. Morgan Securities LLC | 484.154 | 483.587 | |
| 0,40145 % | Hudson Bay Capital Management LP | 465.000 | -100.000 | |
| 0,39420 % | Jump Financial, LLC | 456.601 | -47.208 | |
| 0,39364 % | UBS Asset Management (Switzerland) | 455.959 | 99.247 | |
| 0,36836 % | BNP Paribas Securities Corp. North America | 426.667 | 86.210 | |
| 0,35387 % | American Century Investment Management, Inc. | 409.884 | -61.792 | |
| 0,35088 % | Schroder Investment Management Ltd. (SIM) | 406.425 | 382.425 | |
| 0,34872 % | Goldman Sachs Asset Management, L.P. | 403.917 | 249.157 | |
| 0,34384 % | BlackRock Investment Management, LLC | 398.266 | 28.077 | |
| 0,32082 % | Capital Fund Management S.A. | 371.607 | 235.353 | |
| 0,27112 % | Morgan Stanley Smith Barney LLC | 314.038 | -20.714 | |
| 0,26444 % | BofA Global Research (US) | 306.306 | -517.067 | |
| 0,25900 % | Wanjia Asset Management Co., Ltd. | 300.000 | 150.000 | |
| 0,25415 % | IQ EQ Fund Management (Ireland) Limited | 294.387 | 188.178 | |
| 0,24944 % | UBS Switzerland AG | 288.924 | 13.772 | |
| 0,21558 % | Raymond James & Associates, Inc. | 249.711 | 49.592 | |
| 0,20329 % | Amova Asset Management Americas, Inc | 235.466 | 235.466 | |
| 0,20268 % | Graham Capital Management, L.P. | 234.764 | 234.764 | |
| 0,20029 % | Avidity Partners Management LP | 232.000 | 232.000 | |
| 0,19745 % | Discovery Value Fund | 228.701 | -332.860 | |
| 0,19108 % | HRT Financial LP | 221.328 | 133.175 | |
| 0,19078 % | Nuveen LLC | 220.982 | -34.856 | |
| 0,18919 % | JPMorgan Asset Management U.K. Limited | 219.134 | -12.237 | |
| 0,18374 % | Jane Street Capital, L.L.C. | 212.830 | 64.795 | |
| 0,17900 % | Invesco Capital Management LLC | 207.335 | 78.173 | |
| 0,17855 % | BlackRock Advisors (UK) Limited | 206.819 | 4.731 | |
| 0,16969 % | PDT Partners, LLC | 196.550 | -263.696 | |
| 0,16179 % | Schweizerische Nationalbank | 187.400 | 0 | |
| 0,15918 % | GSA Capital Partners LLP | 184.383 | -35.535 | |
| 0,15877 % | BNY Mellon Asset Management | 183.908 | 9.067 | |
| 0,15344 % | Aperio Group, LLC | 177.726 | 47.054 | |
| 0,14870 % | Wells Fargo Advisors | 172.235 | -124.414 | |
| 0,14861 % | BlackRock Asset Management Ireland Limited | 172.132 | -59.357 | |
| 0,14621 % | Pinnacle Associates Ltd. | 169.350 | -45.470 | |
| 0,14180 % | Rhumbline Advisers Ltd. Partnership | 164.246 | 7.408 | |
| 0,13920 % | Group One Trading, L.P. | 161.236 | 144.235 | |
| 0,13486 % | Susquehanna Fundamental Investments, LLC | 156.204 | 0 | |
| 0,13367 % | JP Morgan Asset Management | 154.827 | -66.802 | |
| 0,13248 % | Voya Investment Management LLC | 153.456 | -113.605 | |
| 0,12984 % | Hennion & Walsh Asset Management, Inc. | 150.393 | -2.757 | |
| 0,12864 % | SELECTRA Management Company S.A. | 149.000 | 0 | |
| 0,12637 % | Sydbank | 146.377 | -5.075 | |
| 0,12499 % | Citi Investment Research (US) | 144.781 | -152.625 | |
| 0,12334 % | DWS Investments UK Limited | 142.868 | -13.317 | |
| 0,11900 % | Rockefeller Capital Management | 137.838 | 0 | |
| 0,11893 % | TwinBeech Capital LP | 137.756 | 137.756 | |
| 0,11853 % | Y-Intercept (Hong Kong) Ltd | 137.290 | 137.290 | |
| 0,11788 % | AQR Capital Management, LLC | 136.540 | 45.665 | |
| 0,11526 % | Mirae Asset Global Investments (USA) LLC | 133.507 | -87.578 | |
| 0,11484 % | Engineers Gate Manager, L.P. | 133.014 | 8.450 | |
| 0,11316 % | SG Americas Securities, L.L.C. | 131.070 | 92.485 | |
| 0,11119 % | Rafferty Asset Management LLC | 128.793 | -51.299 | |
| 0,11118 % | Sphera Funds Management Ltd. | 128.780 | -252.300 | |
| 0,10701 % | Cathay Securities Investment Trust Co., Ltd. | 123.954 | -619 | |
| 0,10605 % | Managed Account Advisors LLC | 122.842 | 632 | |
| 0,10472 % | Geneva Capital Management LLC | 121.298 | 3.508 | |
| 0,10357 % | Chase (William J) | 119.967 | 100.000 | |
| 0,09925 % | Tudor Investment Corporation | 114.964 | 46.687 | |
| 0,09892 % | Mellon Investments Corporation | 114.576 | 10.762 | |
| 0,09793 % | Universal-Investment-Gesellschaft mbH | 113.438 | 48.438 | |
| 0,09376 % | Verition Fund Management LLC | 108.605 | -162.829 | |
| 0,09277 % | Legal & General Investment Management Ltd. | 107.459 | 3.591 | |
| 0,09170 % | Oppenheimer Asset Management Inc. | 106.214 | 87.506 | |