| 12,34527 % | Fidelity Management & Research Company LLC | 12.526.748 | 4.927.105 | |
| 10,25932 % | ARK Investment Management LLC | 10.410.137 | 1.562.296 | |
| 9,86805 % | Farallon Capital Management, L.L.C. | 10.013.111 | 85.000 | |
| 9,54675 % | The Vanguard Group, Inc. | 9.687.083 | 837.636 | |
| 6,62483 % | BlackRock Institutional Trust Company, N.A. | 6.722.214 | -37.631 | |
| 4,76075 % | Amova Asset Management Co., Ltd. | 4.830.738 | 101.294 | |
| 4,47436 % | ARCH Venture Partners | 4.540.132 | 0 | |
| 3,58556 % | State Street Investment Management (US) | 3.638.266 | 198.147 | |
| 2,84743 % | Bellevue Asset Management AG | 2.889.288 | 493.358 | |
| 2,38262 % | Kynam Capital Management LP | 2.417.647 | -100.523 | |
| 2,31870 % | T. Rowe Price Associates, Inc. | 2.352.781 | -589.547 | |
| 2,30365 % | Citadel Advisors LLC | 2.337.517 | -162.830 | |
| 2,23409 % | MWG Management, Ltd. | 2.266.934 | 0 | |
| 2,22160 % | Geode Capital Management, L.L.C. | 2.254.261 | 54.806 | |
| 1,73319 % | Dimensional Fund Advisors, L.P. | 1.758.669 | 162.617 | |
| 1,42899 % | Casdin Capital, LLC | 1.450.000 | 24.438 | |
| 1,40279 % | Redmile Group, LLC | 1.423.411 | -186.918 | |
| 1,11540 % | Voloridge Investment Management, LLC | 1.131.793 | 816.357 | |
| 1,09847 % | Two Sigma Investments, LP | 1.114.621 | 640.520 | |
| 1,04145 % | Morgan Stanley & Co. LLC | 1.056.760 | 570.673 | |
| 1,03204 % | Goldman Sachs & Company, Inc. | 1.047.207 | 514.150 | |
| 0,94335 % | UBS Financial Services, Inc. | 957.218 | -389.422 | |
| 0,86801 % | Evans (John M.) | 880.771 | 0 | |
| 0,77637 % | BofA Global Research (US) | 787.786 | 179.844 | |
| 0,76363 % | Charles Schwab Investment Management, Inc. | 774.851 | -1.594 | |
| 0,75047 % | Woodline Partners LP | 761.498 | 887 | |
| 0,72634 % | Northern Trust Investments, Inc. | 737.022 | -29.140 | |
| 0,67139 % | Barclays Bank PLC | 681.261 | 522.769 | |
| 0,60021 % | BlackRock Financial Management, Inc. | 609.036 | -69.023 | |
| 0,58521 % | Qube Research & Technologies Ltd | 593.815 | 593.815 | |
| 0,57946 % | Susquehanna International Group, LLP | 587.977 | 395.556 | |
| 0,49276 % | Integral Health Asset Management, LLC | 500.000 | 500.000 | |
| 0,42841 % | Fidelity Institutional Asset Management | 434.711 | 114.301 | |
| 0,40347 % | Avidity Partners Management LP | 409.400 | -300.117 | |
| 0,37545 % | UBS Asset Management (Switzerland) | 380.966 | 69.495 | |
| 0,34339 % | Caption Management, LLC | 348.435 | 348.435 | |
| 0,31832 % | Vestmark Advisory Solutions, Inc | 323.000 | 168.479 | |
| 0,31694 % | Alphabet, Inc. | 321.604 | 0 | |
| 0,31505 % | Pictet Asset Management Ltd. | 319.680 | 144.836 | |
| 0,30552 % | Jane Street Capital, L.L.C. | 310.010 | 185.843 | |
| 0,29349 % | Baillie Gifford & Co. | 297.803 | -2.334 | |
| 0,28487 % | BlackRock Investment Management, LLC | 289.058 | 18.758 | |
| 0,27614 % | JP Morgan Asset Management | 280.204 | -149.376 | |
| 0,27148 % | BlackRock Advisors (UK) Limited | 275.469 | 1.240 | |
| 0,26117 % | BNP Paribas Securities Corp. North America | 265.008 | 236.207 | |
| 0,26043 % | Peregrine Investment Management Inc. | 264.260 | 40.000 | |
| 0,24158 % | BlackRock Asset Management Ireland Limited | 245.134 | 12.524 | |
| 0,23250 % | Goldman Sachs Asset Management, L.P. | 235.916 | 91.811 | |
| 0,22555 % | Schonfeld Strategic Advisors LLC | 228.862 | 228.862 | |
| 0,22543 % | Nuveen LLC | 228.740 | 32.020 | |
| 0,21783 % | Amova Asset Management Americas, Inc | 221.029 | 221.029 | |
| 0,21610 % | JPMorgan Asset Management U.K. Limited | 219.274 | -12.049 | |
| 0,20368 % | UBS Switzerland AG | 206.676 | 91.527 | |
| 0,20203 % | Tang Capital Management, LLC | 205.000 | 155.000 | |
| 0,19246 % | IQ EQ Fund Management (Ireland) Limited | 195.288 | 130.036 | |
| 0,17780 % | BNY Mellon Asset Management | 180.417 | 21.683 | |
| 0,17010 % | Schweizerische Nationalbank | 172.600 | 0 | |
| 0,16365 % | ExodusPoint Capital Management, LP | 166.055 | 166.055 | |
| 0,15709 % | Pictet Asset Management (Japan) Ltd. | 159.402 | 159.402 | |
| 0,15313 % | TD Asset Management Inc. | 155.380 | -56.400 | |
| 0,14918 % | Rhumbline Advisers Ltd. Partnership | 151.372 | 10.168 | |
| 0,14785 % | Manulife Investment Management (North America) Limited | 150.027 | -20.581 | |
| 0,14783 % | Wanjia Asset Management Co., Ltd. | 150.000 | 0 | |
| 0,14689 % | Trexquant Investment LP | 149.052 | 149.052 | |
| 0,13675 % | Squarepoint Capital LLP | 138.765 | 114.349 | |
| 0,12640 % | Mellon Investments Corporation | 128.259 | -19.549 | |
| 0,12319 % | SELECTRA Management Company S.A. | 125.000 | 0 | |
| 0,12105 % | Rafferty Asset Management LLC | 122.832 | 2.961 | |
| 0,11957 % | Mirae Asset Global Investments (USA) LLC | 121.330 | -48.393 | |
| 0,10803 % | Sydbank | 109.618 | -3.801 | |
| 0,10742 % | BlackRock Investment Management (UK) Ltd. | 108.998 | 7.742 | |
| 0,10729 % | Morgan Stanley Investment Management Inc. (US) | 108.870 | 40 | |
| 0,10726 % | Citi Investment Research (US) | 108.837 | -110.776 | |
| 0,10622 % | Ciaramella (Giuseppe) | 107.782 | -7.434 | |
| 0,10116 % | Legal & General Investment Management Ltd. | 102.646 | 8.023 | |
| 0,09851 % | Marshall Wace LLP | 99.959 | -169.170 | |
| 0,09798 % | AllianceBernstein L.P. | 99.420 | 12.810 | |
| 0,09709 % | Morgan Stanley Smith Barney LLC | 98.516 | 15.518 | |
| 0,09326 % | D.A. Davidson & Co.(Research) | 94.630 | 8.949 | |
| 0,08879 % | T. Rowe Price International Ltd | 90.095 | 5.722 | |
| 0,08272 % | Invesco Capital Management LLC | 83.931 | 36.884 | |
| 0,08183 % | California State Teachers Retirement System | 83.033 | 231 | |
| 0,08007 % | Baillie Gifford Overseas Ltd. | 81.246 | 0 | |
| 0,07884 % | Emany (Sravan Kumar) | 80.000 | 80.000 | |
| 0,07001 % | Northern Trust Global Investments Limited | 71.044 | 6.149 | |
| 0,06926 % | Universal-Investment-Gesellschaft mbH | 70.280 | 33.065 | |
| 0,06806 % | Yiheng Capital Management, L.P. | 69.058 | 0 | |
| 0,06575 % | UBS Fund Management (Switzerland) AG | 66.713 | -14.955 | |
| 0,06327 % | Dimensional Fund Advisors, Ltd. | 64.199 | 0 | |
| 0,06263 % | Managed Account Advisors LLC | 63.550 | -2.288 | |
| 0,06206 % | Crestline Investors, Inc. | 62.969 | 45.554 | |
| 0,06182 % | DWS Investments UK Limited | 62.727 | -11.358 | |
| 0,05974 % | Nelsen (Robert Taylor) | 60.615 | 0 | |
| 0,05974 % | The Clarius Group, LLC | 60.615 | 0 | |
| 0,05954 % | JPMorgan Private Bank (United States) | 60.418 | -11.490 | |
| 0,05736 % | Millennium Management LLC | 58.204 | 21.724 | |
| 0,05576 % | MetLife Investment Management, LLC | 56.576 | 1.568 | |
| 0,05575 % | Simplex Trading, LLC | 56.570 | 40.103 | |
| 0,05238 % | Harvest Fund Management Co., Ltd. | 53.151 | 23.900 | |
| 0,05095 % | Cathay Securities Investment Trust Co., Ltd. | 51.701 | -258 | |