10.07109 % | Wellington Management Company, LLP | 7,029,624 | 1,915,021 | |
9.85137 % | Janus Henderson Investors | 6,876,253 | -74,165 | |
7.78221 % | RTW Investments L.P. | 5,431,985 | 115,089 | |
7.49855 % | General Atlantic LLC | 5,233,989 | 0 | |
7.09066 % | BlackRock Institutional Trust Company, N.A. | 4,949,278 | 536,267 | |
5.80158 % | T. Rowe Price Associates, Inc. | 4,049,501 | -750,782 | |
5.29219 % | The Vanguard Group, Inc. | 3,693,947 | 35,167 | |
4.00237 % | Alkeon Capital Management LLC | 2,793,653 | 0 | |
3.61784 % | Pfizer Inc | 2,525,252 | 0 | |
3.58588 % | State Street Global Advisors (US) | 2,502,946 | -186,480 | |
2.73332 % | AllianceBernstein L.P. | 1,907,857 | 286,595 | |
2.53187 % | T. Rowe Price Investment Management, Inc. | 1,767,243 | 665,194 | |
2.40220 % | Boxer Capital, L.L.C. | 1,676,733 | 0 | |
2.31954 % | Geode Capital Management, L.L.C. | 1,619,039 | 199,732 | |
2.31300 % | Redmile Group, LLC | 1,614,473 | -244,229 | |
2.14885 % | Perceptive Advisors LLC | 1,499,897 | 112,426 | |
2.05470 % | Yiheng Capital Management, L.P. | 1,434,179 | 0 | |
1.57175 % | Baker Bros. Advisors LP | 1,097,082 | -1,616,123 | |
1.55358 % | Braidwell LP | 1,084,400 | 1,084,400 | |
1.53906 % | Rock Springs Capital Management LP | 1,074,261 | -225,627 | |
1.34617 % | Emerald Advisers LLC | 939,628 | -525 | |
1.25803 % | Morgan Stanley & Co. LLC | 878,103 | 555,950 | |
1.14613 % | Logos Global Management LLC | 800,000 | 0 | |
1.03095 % | Long Focus Capital Management LLC | 719,604 | 391,000 | |
0.89554 % | SilverArc Capital Management, LLC | 625,087 | 225,138 | |
0.81432 % | Goldman Sachs & Company, Inc. | 568,397 | 78,844 | |
0.79494 % | Charles Schwab Investment Management, Inc. | 554,865 | 36,579 | |
0.76442 % | Oppenheimer Asset Management Inc. | 533,567 | 0 | |
0.72674 % | Northern Trust Investments, Inc. | 507,268 | -10,898 | |
0.68465 % | Cheng (Andrew) | 477,884 | 0 | |
0.63294 % | Schonfeld Strategic Advisors LLC | 441,794 | -253,929 | |
0.60723 % | University of Wisconsin Foundation | 423,849 | 51,274 | |
0.59925 % | JP Morgan Asset Management | 418,276 | 151,546 | |
0.56607 % | Citadel Advisors LLC | 395,117 | -24,543 | |
0.55299 % | MPM BioImpact LLC | 385,990 | 53,066 | |
0.46956 % | Propel Bio Management, LLC | 327,752 | 0 | |
0.45232 % | D. E. Shaw & Co., L.P. | 315,717 | -91,408 | |
0.40740 % | Harrison (Seth Loring) | 284,364 | 0 | |
0.40598 % | Octagon Capital Advisors LP | 283,372 | -56,628 | |
0.39542 % | Rheos Capital Works Inc. | 276,000 | 60,000 | |
0.39271 % | BlackRock Financial Management, Inc. | 274,113 | 96,651 | |
0.36896 % | Jane Street Capital, L.L.C. | 257,534 | 7,459 | |
0.35310 % | Schroder Investment Management Ltd. (SIM) | 246,463 | 75,507 | |
0.35185 % | Young (Jonathan) | 245,592 | -10,000 | |
0.35170 % | Simplify Asset Management Inc | 245,487 | -189 | |
0.34348 % | BofA Global Research (US) | 239,749 | -168,828 | |
0.34025 % | Ensign Peak Advisors, Inc. | 237,494 | 4,950 | |
0.30738 % | Goldman Sachs Asset Management, L.P. | 214,553 | 114,254 | |
0.28715 % | Woodline Partners LP | 200,432 | 71,991 | |
0.27770 % | Voloridge Investment Management, LLC | 193,836 | 193,836 | |
0.26846 % | BlackRock Investment Management, LLC | 187,383 | 43,331 | |
0.26490 % | DWS Investments UK Limited | 184,902 | 1,986 | |
0.24625 % | Nuveen LLC | 171,883 | 28,559 | |
0.24325 % | BNY Mellon Asset Management | 169,786 | 25,035 | |
0.24297 % | Millennium Management LLC | 169,591 | -622,984 | |
0.22148 % | TD Asset Management Inc. | 154,592 | 29,600 | |
0.20289 % | Sphera Funds Management Ltd. | 141,620 | -18,825 | |
0.20182 % | DWS Investment GmbH | 140,873 | 0 | |
0.19956 % | PDT Partners, LLC | 139,296 | 14,848 | |
0.19796 % | Two Sigma Investments, LP | 138,174 | 93,887 | |
0.19343 % | Rolph (Timothy Peter) | 135,011 | -537 | |
0.17735 % | Fred Alger Management, LLC | 123,788 | -1,213,093 | |
0.17673 % | abrdn Inc. | 123,358 | -75,879 | |
0.17337 % | Rafferty Asset Management LLC | 121,014 | -173,099 | |
0.15378 % | Rhumbline Advisers Ltd. Partnership | 107,338 | 24,940 | |
0.15354 % | Manulife Investment Management (North America) Limited | 107,172 | 22,195 | |
0.14613 % | Schweizerische Nationalbank | 102,000 | -3,000 | |
0.13875 % | T. Rowe Price International Ltd | 96,850 | 4,052 | |
0.13450 % | Invesco Capital Management LLC | 93,882 | 76,034 | |
0.11839 % | BlackRock Advisors (UK) Limited | 82,634 | 1,212 | |
0.11624 % | Mellon Investments Corporation | 81,134 | 36,901 | |
0.10716 % | Northern Trust Global Investments | 74,798 | 1,260 | |
0.10188 % | UBS Financial Services, Inc. | 71,111 | -136,890 | |
0.10028 % | Connor, Clark & Lunn Investment Management Ltd. | 69,995 | -32,607 | |
0.09965 % | BlackRock Asset Management Ireland Limited | 69,553 | 8,688 | |
0.09483 % | Aperio Group, LLC | 66,194 | 7,856 | |
0.09006 % | Algert Global LLC | 62,861 | -24,562 | |
0.08792 % | JPMorgan Private Bank (United States) | 61,371 | 15,203 | |
0.08118 % | Legal & General Investment Management Ltd. | 56,663 | 6,736 | |
0.07813 % | Barclays Bank PLC | 54,537 | -14,665 | |
0.07778 % | J.P. Morgan Securities LLC | 54,288 | 54,288 | |
0.07728 % | Alps Advisors, Inc. | 53,939 | 14,230 | |
0.07467 % | MFS Investment Management | 52,119 | 0 | |
0.07424 % | California State Teachers Retirement System | 51,821 | -2,364 | |
0.06734 % | Erste Asset Management GmbH | 47,000 | 0 | |
0.06526 % | Jump Financial, LLC | 45,553 | -61,722 | |
0.05695 % | NEOS Investment Management, LLC | 39,754 | 8,225 | |
0.05625 % | Parametric Portfolio Associates LLC | 39,265 | -18,017 | |
0.05622 % | MetLife Investment Management, LLC | 39,243 | 7,003 | |
0.05377 % | Mirae Asset Global Investments (USA) LLC | 37,534 | 11,876 | |
0.05348 % | BlackRock Investment Management (UK) Ltd. | 37,330 | 0 | |
0.05225 % | Corebridge Financial Inc | 36,473 | 36,473 | |
0.05077 % | Susquehanna International Group, LLP | 35,437 | -68,683 | |
0.04917 % | Tudor Investment Corporation | 34,319 | -1,876 | |
0.04900 % | T. Rowe Price Japan, Inc. | 34,199 | 34,199 | |
0.04890 % | UBS Asset Management (Switzerland) | 34,134 | 9,075 | |
0.04571 % | Guggenheim Investments | 31,903 | 6,866 | |
0.04510 % | UBS Fund Management (Switzerland) AG | 31,480 | -15,067 | |
0.04435 % | State of Wisconsin Investment Board | 30,954 | -1,827 | |
0.04345 % | SunAmerica Asset Management, LLC | 30,326 | 4,812 | |