15.94397 % | BVF Partners L.P. | 9,135,893 | 0 | 30/6/2567 |
9.60489 % | Paradigm BioCapital Advisors LP | 5,503,600 | -2,400,000 | 1/8/2567 |
6.98080 % | Deep Track Capital LP | 4,000,000 | 774,581 | 30/6/2567 |
6.06310 % | BlackRock Institutional Trust Company, N.A. | 3,474,156 | 671,288 | 30/6/2567 |
5.60546 % | Point72 Asset Management, L.P. | 3,211,927 | 3,211,927 | 30/6/2567 |
5.60013 % | Logos Global Management LLC | 3,208,875 | -1,175,000 | 30/6/2567 |
4.77420 % | The Vanguard Group, Inc. | 2,735,614 | 334,976 | 30/6/2567 |
4.63328 % | MPM BioImpact LLC | 2,654,867 | 701,177 | 30/6/2567 |
3.39961 % | State Street Global Advisors (US) | 1,947,977 | -1,230,450 | 30/6/2567 |
3.26999 % | Vivo Capital, LLC | 1,873,704 | 0 | 30/6/2567 |
2.94053 % | Dimensional Fund Advisors, L.P. | 1,684,924 | -251,233 | 30/6/2567 |
2.80896 % | Candriam Luxembourg S.A. | 1,609,535 | 0 | 30/9/2567 |
1.85009 % | Geode Capital Management, L.L.C. | 1,060,099 | 220,754 | 30/6/2567 |
1.84760 % | Candriam Belgium S.A. | 1,058,673 | 705,655 | 30/6/2567 |
1.74520 % | Polar Capital LLP | 1,000,000 | 250,000 | 30/6/2567 |
1.57986 % | Wellington Management Company, LLP | 905,257 | 69,644 | 30/6/2567 |
1.52410 % | Harmon (Cyrus) | 873,311 | -10,000 | 30/7/2567 |
1.48788 % | Woodline Partners LP | 852,554 | 102,275 | 30/6/2567 |
1.39072 % | Great Point Partners, LLC | 796,880 | 796,880 | 30/6/2567 |
1.35217 % | Victory Capital Management Inc. | 774,792 | 164,143 | 30/6/2567 |
1.13438 % | Boxer Capital, L.L.C. | 650,000 | 650,000 | 30/6/2567 |
1.02792 % | Marshall Wace LLP | 588,996 | 41,193 | 30/6/2567 |
0.98377 % | Myles (David C) | 563,701 | 1,880 | 22/11/2566 |
0.95986 % | Ghost Tree Capital, LLC | 550,000 | 350,000 | 30/6/2567 |
0.95439 % | SilverArc Capital Management, LLC | 546,863 | 31,546 | 30/6/2567 |
0.84640 % | Kovacs Shane William Charles | 484,987 | 10,782 | 23/4/2567 |
0.74021 % | Columbia Threadneedle Investments (US) | 424,141 | 130,976 | 30/6/2567 |
0.67359 % | Rappaport (Andrew) | 385,965 | -95,049 | 23/4/2567 |
0.63085 % | Goldman Sachs & Company, Inc. | 361,479 | 24,078 | 30/6/2567 |
0.58580 % | BlackRock Financial Management, Inc. | 335,665 | 64,979 | 30/6/2567 |
0.56719 % | Adage Capital Management, L.P. | 325,000 | -135,000 | 30/6/2567 |
0.54384 % | Two Sigma Investments, LP | 311,620 | 67,306 | 30/6/2567 |
0.52586 % | Northern Trust Investments, Inc. | 301,317 | -923 | 30/6/2567 |
0.52307 % | Morgan Stanley & Co. LLC | 299,720 | -181,320 | 30/6/2567 |
0.47993 % | Affinity Asset Advisors LLC | 275,000 | 275,000 | 30/6/2567 |
0.43387 % | DWS Investments UK Limited | 248,609 | 4,844 | 30/6/2567 |
0.43260 % | HighVista Strategies LLC | 247,880 | 0 | 30/6/2567 |
0.37784 % | Soleus Capital Management, L.P. | 216,500 | -441,500 | 30/6/2567 |
0.36402 % | AllianceBernstein L.P. | 208,583 | 183,493 | 30/6/2567 |
0.27878 % | Schroder Investment Management Ltd. (SIM) | 159,739 | 159,739 | 30/6/2567 |
0.27683 % | UBS Financial Services, Inc. | 158,625 | -14,536 | 30/6/2567 |
0.25292 % | Bohen (Sean) | 144,925 | 12,621 | 23/4/2567 |
0.24433 % | Newtyn Management, LLC | 140,000 | -10,000 | 30/6/2567 |
0.23280 % | BofA Global Research (US) | 133,395 | -193,424 | 30/6/2567 |
0.23081 % | Citadel Advisors LLC | 132,253 | -648,407 | 30/6/2567 |
0.21500 % | Charles Schwab Investment Management, Inc. | 123,196 | 36,239 | 30/6/2567 |
0.20677 % | Sectoral Asset Management Inc. | 118,480 | -21,500 | 30/6/2567 |
0.20542 % | BlackRock Investment Management, LLC | 117,705 | 41,684 | 30/6/2567 |
0.20523 % | Hennion & Walsh Asset Management, Inc. | 117,595 | 30,283 | 30/9/2567 |
0.20406 % | Schonfeld Strategic Advisors LLC | 116,926 | -86,899 | 30/6/2567 |
0.20199 % | Nuveen LLC | 115,742 | 17,545 | 30/6/2567 |
0.20007 % | Trexquant Investment LP | 114,642 | 114,642 | 30/6/2567 |
0.17802 % | Rafferty Asset Management LLC | 102,006 | -192,713 | 30/6/2567 |
0.16005 % | BNY Mellon Asset Management | 91,707 | 28,666 | 30/6/2567 |
0.15676 % | Zojwalla (Naseem M.D.) | 89,824 | 9,460 | 24/5/2567 |
0.15253 % | Jacobs Levy Equity Management, Inc. | 87,397 | 12,478 | 30/6/2567 |
0.15070 % | Dimensional Fund Advisors, Ltd. | 86,352 | -12,095 | 30/9/2567 |
0.14638 % | Butitta (Cynthia M) | 83,876 | 0 | 23/4/2567 |
0.13852 % | JP Morgan Asset Management | 79,370 | -87 | 31/8/2567 |
0.13029 % | Dana Investment Advisors, Inc. | 74,657 | 74,657 | 30/6/2567 |
0.12518 % | MFS Investment Management | 71,730 | -12,750 | 31/8/2567 |
0.11542 % | Susquehanna International Group, LLP | 66,138 | 18,102 | 30/6/2567 |
0.11518 % | Schweizerische Nationalbank | 66,000 | -4,300 | 30/6/2567 |
0.11021 % | ClariVest Asset Management LLC | 63,149 | 1,881 | 30/6/2567 |
0.10710 % | State of Wisconsin Investment Board | 61,369 | 37,235 | 30/6/2567 |
0.10342 % | Rhumbline Advisers Ltd. Partnership | 59,261 | 17,953 | 30/6/2567 |
0.10173 % | Florida State Board of Administration | 58,290 | -5,100 | 30/6/2567 |
0.09960 % | Squarepoint Capital LLP | 57,070 | -16,519 | 30/6/2567 |
0.09773 % | Janus Henderson Investors | 56,000 | -1,165,662 | 30/6/2567 |
0.09284 % | Renaissance Technologies LLC | 53,200 | 53,200 | 30/6/2567 |
0.09190 % | Jane Street Capital, L.L.C. | 52,661 | 17,007 | 30/6/2567 |
0.08590 % | Envestnet Asset Management, Inc. | 49,220 | 49,220 | 30/6/2567 |
0.08071 % | EP Wealth Advisors, LLC | 46,248 | 0 | 30/6/2567 |
0.07863 % | UBS Asset Management (Switzerland) | 45,055 | 16,265 | 30/6/2567 |
0.07775 % | Barclays Bank PLC | 44,548 | 3,185 | 30/6/2567 |
0.07722 % | BlackRock Advisors (UK) Limited | 44,248 | 700 | 30/9/2567 |
0.07711 % | BlackRock Asset Management Ireland Limited | 44,186 | 1,955 | 30/6/2567 |
0.07618 % | Alps Advisors, Inc. | 43,652 | 4,791 | 30/6/2567 |
0.06916 % | Goldman Sachs Asset Management, L.P. | 39,626 | -60,004 | 30/6/2567 |
0.06780 % | Allianz Global Investors GmbH | 38,850 | 20,830 | 31/8/2567 |
0.06725 % | UBS Fund Management (Switzerland) AG | 38,535 | -8,911 | 30/6/2567 |
0.06669 % | Northern Trust Global Investments | 38,216 | -3,933 | 30/6/2567 |
0.06024 % | Atom Investors LP | 34,515 | -59,806 | 30/6/2567 |
0.05923 % | Mellon Investments Corporation | 33,936 | 15,676 | 30/6/2567 |
0.05810 % | California State Teachers Retirement System | 33,293 | -1,402 | 30/6/2567 |
0.05614 % | Legal & General Investment Management Ltd. | 32,170 | 4,876 | 30/6/2567 |
0.05538 % | Parametric Portfolio Associates LLC | 31,735 | 16,463 | 30/6/2567 |
0.05510 % | Avantis Investors | 31,572 | -3,638 | 31/3/2567 |
0.05492 % | Voya Investment Management LLC | 31,472 | -98,115 | 30/6/2567 |
0.05481 % | Deerfield Management Company, L.P. | 31,405 | 31,405 | 30/6/2567 |
0.05452 % | T. Rowe Price International Ltd | 31,242 | 4,991 | 30/6/2567 |
0.05339 % | Jump Financial, LLC | 30,592 | 30,592 | 30/6/2567 |
0.04916 % | Connor, Clark & Lunn Investment Management Ltd. | 28,167 | -23,755 | 30/6/2567 |
0.04714 % | Pitcairn | 27,013 | 27,013 | 30/6/2567 |
0.04633 % | Susquehanna Portfolio Strategies, LLC | 26,549 | -8,059 | 30/6/2567 |
0.04564 % | Pictet Asset Management Ltd. | 26,154 | 0 | 31/8/2567 |
0.04145 % | Citi Investment Research (US) | 23,752 | -226,230 | 30/6/2567 |
0.04135 % | MetLife Investment Management, LLC | 23,695 | 8,790 | 30/6/2567 |
0.03897 % | Brevan Howard Capital Management LP | 22,328 | 22,328 | 30/6/2567 |
0.03891 % | Assenagon Asset Management S.A. | 22,295 | 342 | 30/9/2567 |