9.21 % | EcoR1 Capital, LLC | 1,11,73,068 | 2,73,209 | 31/12/2023 |
9.15 % | Avoro Capital Advisors LLC | 1,11,11,111 | 0 | 31/12/2023 |
7.86 % | The Vanguard Group, Inc. | 95,37,719 | 85,701 | 31/12/2023 |
5.19 % | T. Rowe Price Investment Management, Inc. | 63,03,584 | -2,15,887 | 31/12/2023 |
3.98 % | BlackRock Institutional Trust Company, N.A. | 48,32,877 | 92,717 | 31/12/2023 |
2.70 % | Jennison Associates LLC | 32,75,922 | -2,66,287 | 31/12/2023 |
2.40 % | State Street Global Advisors (US) | 29,15,422 | -3,22,692 | 31/12/2023 |
2.31 % | Octagon Capital Advisors LP | 28,06,980 | -3,23,020 | 31/12/2023 |
2.30 % | Morgan Stanley & Co. LLC | 27,95,240 | 16,01,542 | 31/12/2023 |
13.55 % | Wellington Management Company, LLP | 1,64,45,290 | 12,78,246 | 31/12/2023 |
10.55 % | Morningside Venture Investments, Ltd. | 1,28,06,342 | 0 | 31/3/2023 |
1.98 % | T. Rowe Price Associates, Inc. | 23,98,842 | 6,69,759 | 31/12/2023 |
1.77 % | Assenagon Asset Management S.A. | 21,45,004 | 11,21,497 | 31/12/2023 |
1.72 % | Fidelity Management & Research Company LLC | 20,92,464 | -1,67,086 | 31/12/2023 |
1.42 % | Boxer Capital, L.L.C. | 17,26,000 | 0 | 31/12/2023 |
1.41 % | JP Morgan Asset Management | 17,16,070 | 70,134 | 31/12/2023 |
1.34 % | Geode Capital Management, L.L.C. | 16,30,642 | 75,816 | 31/12/2023 |
1.17 % | Invus Public Equities Advisors, LLC | 14,21,346 | -2,43,226 | 31/12/2023 |
1.11 % | Pictet Asset Management Ltd. | 13,44,563 | 6,10,413 | 31/12/2023 |
0.88 % | Deschatelets (Pascal) | 10,63,301 | 0 | 8/4/2024 |
0.87 % | Polar Capital LLP | 10,53,440 | -435 | 31/12/2023 |
0.78 % | Logos Global Management LLC | 9,50,000 | 2,00,000 | 31/12/2023 |
0.78 % | Norges Bank Investment Management (NBIM) | 9,46,213 | -1,01,241 | 31/12/2023 |
0.76 % | OrbiMed Advisors, LLC | 9,22,200 | -3,38,300 | 31/12/2023 |
0.76 % | Fiera Capital Corporation | 9,19,090 | -600 | 31/12/2023 |
0.75 % | Charles Schwab Investment Management, Inc. | 9,04,409 | 25,052 | 31/12/2023 |
0.73 % | Frazier Healthcare Partners | 8,85,165 | 2,71,122 | 31/12/2023 |
0.68 % | Bellevue Asset Management AG | 8,21,800 | 27,959 | 31/12/2023 |
0.64 % | Machiels (Alec) | 7,78,844 | 3,341 | 1/1/2024 |
0.54 % | Francois (Cedric G) | 6,53,418 | 0 | 1/3/2024 |
0.51 % | Cormorant Asset Management, LP | 6,25,000 | -13,75,000 | 31/12/2023 |
0.51 % | Victory Capital Management Inc. | 6,16,272 | -1,22,239 | 31/12/2023 |
0.50 % | JPMorgan Asset Management U.K. Limited | 6,11,840 | 1,37,145 | 31/12/2023 |
0.48 % | Macquarie Investment Management | 5,83,429 | -4,93,119 | 31/12/2023 |
0.41 % | Invesco Advisers, Inc. | 4,94,709 | 2,597 | 31/12/2023 |
0.40 % | Columbia Threadneedle Investments (US) | 4,89,522 | 2,13,188 | 31/12/2023 |
0.40 % | TD Asset Management Inc. | 4,83,322 | 1,12,465 | 31/12/2023 |
0.40 % | Driehaus Capital Management, LLC | 4,81,501 | 3,00,177 | 31/12/2023 |
0.38 % | Candriam Luxembourg S.A. | 4,64,507 | 95,000 | 29/2/2024 |
0.37 % | Eagle Asset Management, Inc. | 4,46,000 | -3,970 | 31/12/2023 |
0.36 % | Jane Street Capital, L.L.C. | 4,34,701 | 1,61,475 | 31/12/2023 |
0.33 % | Dunlop (Sinclair Andrew) | 4,02,185 | 1,500 | 12/4/2024 |
0.32 % | Caption Management, LLC | 3,93,031 | 1,19,781 | 31/12/2023 |
0.32 % | Northern Trust Investments, Inc. | 3,87,643 | 18,292 | 31/12/2023 |
0.32 % | Susquehanna International Group, LLP | 3,82,832 | 10,047 | 31/12/2023 |
0.30 % | BMO Capital Markets (US) | 3,68,510 | -62,000 | 31/12/2023 |
0.30 % | DWS Investments UK Limited | 3,59,928 | 3,56,000 | 31/12/2023 |
0.28 % | New York State Common Retirement Fund | 3,40,507 | -62,437 | 31/12/2023 |
0.28 % | Candriam Belgium S.A. | 3,37,507 | 11,000 | 31/12/2023 |
0.27 % | PGIM Securities Investment Trust Enterprise | 3,24,000 | 23,000 | 31/12/2023 |
0.23 % | Citadel Advisors LLC | 2,85,117 | 2,70,370 | 31/12/2023 |
0.23 % | Medical Strategy GmbH | 2,82,365 | -6,200 | 31/12/2023 |
0.22 % | Nuveen LLC | 2,66,739 | -6,439 | 31/12/2023 |
0.21 % | Voya Investment Management LLC | 2,56,533 | 1,74,366 | 31/12/2023 |
0.21 % | Group One Trading, L.P. | 2,53,905 | 27,221 | 31/12/2023 |
0.20 % | Ensign Peak Advisors, Inc. | 2,45,566 | 60,000 | 31/12/2023 |
0.20 % | Fiduciary Trust Company | 2,42,607 | -22,600 | 31/12/2023 |
0.20 % | Amundi Asset Management US, Inc. | 2,41,371 | 1,35,315 | 31/12/2023 |
0.19 % | Marshall Wace LLP | 2,30,876 | 61,582 | 31/12/2023 |
0.19 % | Franklin Advisers, Inc. | 2,29,622 | 2,29,622 | 31/12/2023 |
0.17 % | Eventide Asset Management, LLC | 2,09,794 | 2,09,794 | 31/12/2023 |
0.17 % | Great Lakes Advisors, LLC | 2,08,163 | 2,08,163 | 31/12/2023 |
0.17 % | Managed Account Advisors LLC | 2,01,764 | -1,38,260 | 31/12/2023 |
0.16 % | Barclays Bank PLC | 1,94,813 | -1,33,008 | 31/12/2023 |
0.16 % | Goldman Sachs Asset Management, L.P. | 1,91,449 | -31,387 | 31/12/2023 |
0.16 % | DWS Investment S.A. | 1,90,889 | 1,90,889 | 31/12/2023 |
0.16 % | DWS Investment GmbH | 1,88,493 | -15,577 | 31/12/2023 |
0.15 % | BNY Mellon Asset Management | 1,87,210 | 3,829 | 31/12/2023 |
0.15 % | Woodline Partners LP | 1,86,224 | 1,86,224 | 31/12/2023 |
0.15 % | BlackRock Financial Management, Inc. | 1,84,605 | -347 | 31/12/2023 |
0.14 % | Tekla Capital Management LLC_NLE | 1,73,248 | 38,124 | 30/6/2023 |
0.14 % | abrdn Inc. | 1,69,051 | 1,69,051 | 31/12/2023 |
0.14 % | BNP Paribas Securities Corp. North America | 1,67,488 | -68,867 | 31/12/2023 |
0.13 % | Mellon Investments Corporation | 1,63,694 | -2,386 | 31/12/2023 |
0.13 % | Schweizerische Nationalbank | 1,62,400 | -16,800 | 31/12/2023 |
0.13 % | Altitude Crest Partners Inc | 1,52,200 | 1,52,200 | 31/12/2023 |
0.12 % | Morgan Stanley Smith Barney LLC | 1,51,483 | -1,20,351 | 31/12/2023 |
0.12 % | BlackRock Asset Management Ireland Limited | 1,50,301 | 4,920 | 31/12/2023 |
0.12 % | Ally Bridge Group NY LLC | 1,50,000 | -31,805 | 31/12/2023 |
0.12 % | Walleye Capital LLC | 1,47,674 | 13,691 | 31/12/2023 |
0.12 % | California Public Employees' Retirement System | 1,45,833 | -38,011 | 31/12/2023 |
0.12 % | J.P. Morgan Securities plc | 1,45,342 | 1,45,342 | 31/12/2023 |
0.12 % | Rafferty Asset Management LLC | 1,43,118 | -71,043 | 31/12/2023 |
0.12 % | Saturn V Capital Management LLC | 1,42,927 | 1,42,927 | 31/12/2023 |
0.11 % | Rhumbline Advisers Ltd. Partnership | 1,33,586 | 1,292 | 31/12/2023 |
0.11 % | Pictet Asset Management (Japan) Ltd. | 1,31,404 | 1,31,404 | 31/10/2023 |
0.11 % | Lombard Odier Asset Management (Europe) Ltd | 1,31,098 | -38,956 | 30/9/2022 |
0.11 % | 683 Capital Management LLC | 1,30,000 | -1,10,000 | 31/12/2023 |
0.10 % | Wells Fargo Advisors | 1,25,206 | 15,309 | 31/12/2023 |
0.10 % | PNC Investments LLC | 1,19,653 | 57 | 31/12/2023 |
0.10 % | BofA Global Research (US) | 1,19,017 | -2,45,914 | 31/12/2023 |
0.10 % | Allspring Global Investments, LLC | 1,15,453 | 56,178 | 31/3/2024 |
0.09 % | Goldman Sachs & Company, Inc. | 1,14,810 | 5,853 | 31/12/2023 |
0.09 % | LMR Partners LLP | 1,14,069 | 56,940 | 31/12/2023 |
0.09 % | Cutter Capital Management, LP | 1,08,000 | 1,08,000 | 31/12/2023 |
0.09 % | Manulife Investment Management (North America) Limited | 1,06,002 | 51,737 | 31/12/2023 |
0.08 % | Parametric Portfolio Associates LLC | 1,00,752 | 14,566 | 31/12/2023 |
0.08 % | Rhenman & Partners Asset Management AB | 1,00,400 | -1,14,600 | 31/12/2023 |
0.08 % | BMO Nesbitt Burns Inc. | 99,800 | 99,800 | 31/12/2023 |
0.08 % | Thrivent Asset Management, LLC | 97,716 | 18,255 | 31/12/2023 |