7.64205 % | Avidity Partners Management LP | 6,500,328 | -324,122 | 12/31/2023 |
7.52528 % | Deerfield Management Company, L.P. | 6,401,000 | 3,578,000 | 12/31/2023 |
6.24535 % | Fidelity Management & Research Company LLC | 5,312,297 | 1,135,446 | 12/31/2023 |
5.56924 % | Perceptive Advisors LLC | 4,737,194 | 1,985,799 | 1/9/2024 |
4.51529 % | HealthCap AB | 3,840,702 | 33,455 | 3/18/2024 |
4.31521 % | Johnson & Johnson Innovation-JJDC, Inc. | 3,670,516 | 0 | 12/31/2023 |
3.82903 % | Varian Medical Systems, Inc. | 3,256,972 | 3,256,972 | 2/17/2023 |
3.67126 % | OrbiMed Advisors, LLC | 3,122,770 | 0 | 12/31/2023 |
3.66443 % | CPP Investment Board | 3,116,966 | 0 | 12/31/2023 |
3.46556 % | Adams Street Partners, LLC | 2,947,809 | 0 | 12/31/2023 |
2.99999 % | TPG Capital, L.P. | 2,551,794 | 0 | 12/31/2023 |
12.77469 % | Federated Hermes Global Investment Management Corp. | 10,866,153 | 282,364 | 12/31/2023 |
1.83515 % | Pivotal Bioventure Partners Investment Advisor LLC | 1,560,982 | 0 | 12/31/2023 |
1.27632 % | Sphera Funds Management Ltd. | 1,085,639 | -268,619 | 12/31/2023 |
1.18211 % | Invus Public Equities Advisors, LLC | 1,005,500 | -719,500 | 12/31/2023 |
1.16842 % | William Blair & Company, L.L.C. (Research) | 993,855 | 993,855 | 12/31/2023 |
0.87523 % | Wellington Management Company, LLP | 744,474 | 579,949 | 12/31/2023 |
0.86330 % | 1832 Asset Management L.P. | 734,321 | 0 | 12/31/2023 |
0.68160 % | Eagle Health Investments LP | 579,769 | 0 | 12/31/2023 |
0.67964 % | Millennium Management LLC | 578,102 | -4,027 | 12/31/2023 |
0.58782 % | Ikarian Capital LLC | 500,000 | 500,000 | 12/31/2023 |
0.47026 % | Adage Capital Management, L.P. | 400,000 | 400,000 | 12/31/2023 |
0.44696 % | BlackRock Institutional Trust Company, N.A. | 380,187 | 375,975 | 12/31/2023 |
0.37437 % | Marshall Wace LLP | 318,440 | 318,440 | 12/31/2023 |
0.37403 % | Valliant (John Fitzmaurice) | 318,147 | 0 | 2/17/2023 |
0.36677 % | Fred Alger Management, LLC | 311,974 | 311,974 | 12/31/2023 |
0.35389 % | Jennison Associates LLC | 301,020 | 301,020 | 12/31/2023 |
0.34518 % | Point72 Asset Management, L.P. | 293,611 | -35,257 | 12/31/2023 |
0.32578 % | Pier Capital, LLC | 277,111 | 277,111 | 12/31/2023 |
0.29534 % | Walleye Capital LLC | 251,213 | 251,213 | 12/31/2023 |
0.28925 % | Sio Capital Management, LLC | 246,036 | 0 | 12/31/2023 |
0.26228 % | UBS Financial Services, Inc. | 223,092 | 129,783 | 12/31/2023 |
0.26154 % | Woodline Partners LP | 222,462 | 144,427 | 12/31/2023 |
0.25054 % | UBS O'Connor LLC | 213,107 | -61,461 | 12/31/2023 |
0.18080 % | Schonfeld Strategic Advisors LLC | 153,792 | 153,792 | 12/31/2023 |
0.17203 % | Morgan Stanley Smith Barney LLC | 146,328 | -19,732 | 12/31/2023 |
0.16665 % | Privium Fund Management BV | 141,750 | 141,750 | 12/31/2023 |
0.15701 % | Boothbay Fund Management, LLC | 133,550 | 133,550 | 12/31/2023 |
0.15334 % | Two Sigma Investments, LP | 130,433 | 98,333 | 12/31/2023 |
0.15330 % | Atika Capital Management LLC | 130,400 | 130,400 | 12/31/2023 |
0.14731 % | Sofinnova Investments, Inc | 125,299 | 8,200 | 12/31/2023 |
0.14696 % | Healthinvest Partners AB | 125,000 | 0 | 12/31/2023 |
0.12860 % | Verition Fund Management LLC | 109,386 | 109,386 | 12/31/2023 |
0.10475 % | Franklin Advisers, Inc. | 89,100 | 89,100 | 1/31/2024 |
0.10361 % | Invesco Advisers, Inc. | 88,130 | 25,451 | 2/29/2024 |
0.10134 % | Jump Financial, LLC | 86,199 | 86,199 | 12/31/2023 |
0.09037 % | Yarbrough Capital, LLC | 76,872 | 0 | 3/31/2024 |
0.07932 % | Cubist Systematic Strategies, LLC | 67,470 | 67,460 | 12/31/2023 |
0.07084 % | Morgan Stanley & Co. LLC | 60,253 | 60,253 | 12/31/2023 |
0.06954 % | BlackRock Investment Management, LLC | 59,154 | -2,263 | 2/29/2024 |
0.06736 % | Sectoral Asset Management Inc. | 57,297 | 0 | 12/31/2023 |
0.06631 % | Gannon (Steven R) | 56,400 | 0 | 2/17/2023 |
0.06595 % | abrdn Investments Limited | 56,100 | 56,100 | 3/31/2024 |
0.06363 % | Citadel Advisors LLC | 54,123 | 54,123 | 12/31/2023 |
0.05865 % | Chartwell Investment Partners, LLC | 49,890 | 49,890 | 12/31/2023 |
0.05705 % | Avantis Investors | 48,526 | 48,526 | 3/31/2024 |
0.05659 % | Assenagon Asset Management S.A. | 48,138 | 3,536 | 2/29/2024 |
0.05385 % | Superstring Capital Management LP | 45,801 | 45,801 | 12/31/2023 |
0.05173 % | Medical Strategy GmbH | 44,000 | 44,000 | 12/31/2023 |
0.05102 % | Tekla Capital Management LLC_NLE | 43,394 | 0 | 6/30/2023 |
0.04949 % | Khuong (Chau Quang) | 42,093 | 0 | 2/17/2023 |
0.04626 % | Geode Capital Management, L.L.C. | 39,346 | 8,478 | 12/31/2023 |
0.04525 % | Burak (Eric) | 38,490 | 0 | 2/17/2023 |
0.04513 % | BlackRock Advisors (UK) Limited | 38,391 | 1,843 | 3/31/2024 |
0.04183 % | BlackRock Asset Management Ireland Limited | 35,578 | 35,578 | 12/31/2023 |
0.03662 % | Raymond James Financial Services Advisors, Inc. | 31,145 | 31,145 | 12/31/2023 |
0.03637 % | NEOS Investment Management, LLC | 30,939 | 13,446 | 12/31/2023 |
0.03606 % | RBC Capital Markets Wealth Management | 30,669 | 30,669 | 12/31/2023 |
0.03307 % | Jane Street Capital, L.L.C. | 28,132 | 28,132 | 12/31/2023 |
0.02736 % | Driehaus Capital Management, LLC | 23,270 | 0 | 2/29/2024 |
0.02723 % | XTX Markets LLC | 23,161 | 23,161 | 12/31/2023 |
0.02707 % | The Vanguard Group, Inc. | 23,029 | 23,029 | 3/31/2024 |
0.02571 % | Credit Suisse Funds AG | 21,867 | 21,867 | 2/29/2024 |
0.02551 % | abrdn Inc. | 21,697 | 21,697 | 12/31/2023 |
0.02540 % | Goldman Sachs Asset Management, L.P. | 21,605 | -170 | 3/31/2024 |
0.02481 % | T. Rowe Price Associates, Inc. | 21,100 | 21,100 | 2/29/2024 |
0.02375 % | Raymond James & Associates, Inc. | 20,200 | 20,200 | 12/31/2023 |
0.02351 % | Federated Hermes Equity Management Company of Pennsylvania | 20,000 | -80,000 | 12/31/2023 |
0.02249 % | Group One Trading, L.P. | 19,134 | 19,134 | 12/31/2023 |
0.02171 % | Susquehanna International Group, LLP | 18,465 | 18,465 | 12/31/2023 |
0.02072 % | ProShare Advisors LLC | 17,623 | 12,213 | 3/31/2024 |
0.01965 % | Forefront Analytics, LLC | 16,715 | -16,970 | 12/31/2023 |
0.01922 % | Belvedere Trading, LLC | 16,349 | 16,349 | 12/31/2023 |
0.01846 % | Alpine Associates Management Inc. | 15,700 | 15,700 | 3/31/2024 |
0.01779 % | Goldman Sachs & Company, Inc. | 15,132 | 15,132 | 12/31/2023 |
0.01510 % | Rawat (Mohit) | 12,843 | 12,843 | 8/31/2023 |
0.01500 % | Squarepoint Capital LLP | 12,757 | 12,757 | 12/31/2023 |
0.01470 % | Simplex Trading, LLC | 12,501 | 12,422 | 12/31/2023 |
0.01406 % | Leamon (Christopher Paul Ph.D.) | 11,957 | 11,957 | 8/31/2023 |
0.01347 % | Envestnet Asset Management, Inc. | 11,454 | 11,454 | 12/31/2023 |
0.01224 % | Crowley (John Joseph CPA) | 10,410 | 0 | 2/17/2023 |
0.01220 % | Vanguard Investments Australia Ltd. | 10,380 | 10,380 | 2/29/2024 |
0.01176 % | Renaissance Technologies LLC | 10,000 | 10,000 | 12/31/2023 |
0.01127 % | AlphaSimplex Group, LLC | 9,590 | 9,590 | 2/29/2024 |
0.01037 % | Preston (Heather Elizabeth) | 8,823 | 0 | 2/17/2023 |
0.01011 % | Cutler Group, LP | 8,600 | 7,500 | 3/31/2024 |
0.01011 % | Mercer Global Investments Management Ltd | 8,600 | 8,600 | 3/31/2024 |
0.00999 % | State Street Global Advisors Ireland Limited | 8,500 | 8,500 | 3/31/2024 |
0.00987 % | American Century Investment Management, Inc. | 8,399 | 8,399 | 3/31/2024 |
0.00985 % | China Universal Asset Management Co., Ltd. | 8,376 | 8,376 | 12/31/2023 |