9.20473 % | Kynam Capital Management LP | 4,420,349 | 2,747,308 | 12/31/2022 |
7.55686 % | BVF Partners L.P. | 3,629,000 | 0 | 12/31/2022 |
3.97934 % | The Vanguard Group, Inc. | 1,910,984 | 69,214 | 12/31/2022 |
3.60744 % | Nantahala Capital Management, LLC | 1,732,388 | -54,771 | 12/31/2022 |
3.00220 % | Millennium Management LLC | 1,441,735 | 122,227 | 12/31/2022 |
2.89718 % | Citadel Advisors LLC | 1,391,302 | 269,873 | 12/31/2022 |
2.79098 % | Point72 Asset Management, L.P. | 1,340,300 | 1,069,700 | 12/31/2022 |
2.72452 % | BofA Global Research (US) | 1,308,386 | 4,391 | 12/31/2022 |
2.69838 % | Ingalls & Snyder LLC (Asset Management) | 1,295,833 | -34,600 | 12/31/2022 |
2.50608 % | Parkman Healthcare Partners LLC | 1,203,484 | 65,897 | 12/31/2022 |
2.46141 % | BlackRock Institutional Trust Company, N.A. | 1,182,032 | 380,848 | 12/31/2022 |
2.39471 % | Tang Capital Management, LLC | 1,150,000 | 146,983 | 12/31/2022 |
2.26622 % | RA Capital Management, LP | 1,088,296 | 0 | 12/31/2022 |
2.08815 % | Sphera Funds Management Ltd. | 1,002,783 | 50,000 | 12/31/2022 |
2.03927 % | Medical Strategy GmbH | 979,309 | 0 | 9/30/2022 |
1.61366 % | Dimensional Fund Advisors, L.P. | 774,922 | 112,822 | 12/31/2022 |
1.60203 % | Assenagon Asset Management S.A. | 769,336 | -140,554 | 12/31/2022 |
1.56830 % | Acadian Asset Management LLC | 753,140 | 123,841 | 12/31/2022 |
1.38822 % | AWM Investment Company, Inc. | 666,661 | 0 | 12/31/2022 |
1.14145 % | Barclays Bank PLC | 548,155 | 97,922 | 12/31/2022 |
1.14009 % | NewEdge Wealth, LLC | 547,501 | 0 | 12/31/2022 |
1.13113 % | BMO Capital Markets (US) | 543,200 | 543,200 | 12/31/2022 |
1.12151 % | Alyeska Investment Group, L.P. | 538,579 | 38,579 | 12/31/2022 |
1.09038 % | Goldman Sachs & Company, Inc. | 523,630 | 189,551 | 12/31/2022 |
1.08237 % | Morgan Stanley & Co. LLC | 519,782 | -32,140 | 12/31/2022 |
1.04883 % | Schonfeld Strategic Advisors LLC | 503,674 | 244,574 | 12/31/2022 |
1.04244 % | Renaissance Technologies LLC | 500,605 | -142,000 | 12/31/2022 |
1.02265 % | Two Sigma Investments, LP | 491,105 | -365,147 | 12/31/2022 |
0.95823 % | IndexIQ Advisors LLC | 460,165 | 460,165 | 2/28/2023 |
0.87013 % | Geode Capital Management, L.L.C. | 417,858 | 9,369 | 12/31/2022 |
0.60512 % | Connor, Clark & Lunn Investment Management Ltd. | 290,595 | -9,763 | 12/31/2022 |
0.57106 % | J.P. Morgan Securities LLC | 274,240 | 186,915 | 12/31/2022 |
0.50016 % | Susquehanna International Group, LLP | 240,190 | 202,781 | 12/31/2022 |
0.43866 % | Stuart Nancy | 210,654 | -6,048 | 2/15/2023 |
0.43006 % | Pura Vida Investments, LLC | 206,525 | 206,525 | 12/31/2022 |
0.41814 % | International Biotechnology Trust PLC | 200,800 | 0 | 12/31/2022 |
0.40416 % | Citi Investment Research (US) | 194,090 | 73,373 | 12/31/2022 |
0.31849 % | Manulife Investment Management (North America) Limited | 152,947 | 151,883 | 1/31/2023 |
0.30860 % | Bridgeway Capital Management, LLC | 148,200 | 0 | 12/31/2022 |
0.29340 % | State Street Global Advisors (US) | 140,898 | 20,300 | 12/31/2022 |
0.23707 % | D. E. Shaw & Co., L.P. | 113,848 | 113,848 | 12/31/2022 |
0.23656 % | Aberdeen Asset Managers Ltd. | 113,600 | -105,700 | 2/28/2023 |
0.22506 % | Northern Trust Investments, Inc. | 108,079 | -437 | 12/31/2022 |
0.21511 % | ClariVest Asset Management LLC | 103,300 | -1,500 | 12/31/2022 |
0.20824 % | BZ Bank AG (Asset Management) | 100,000 | 0 | 11/30/2022 |
0.18408 % | Florida State Board of Administration | 88,400 | 88,400 | 9/30/2022 |
0.18396 % | Ensign Peak Advisors, Inc. | 88,341 | 0 | 12/31/2022 |
0.18158 % | City National Rochdale, LLC | 87,200 | 87,200 | 12/31/2022 |
0.17490 % | Caxton Associates LP | 83,993 | -40,122 | 12/31/2022 |
0.15524 % | Walleye Capital LLC | 74,548 | 74,548 | 12/31/2022 |
0.14785 % | Black Diamond Financial, LLC | 71,000 | 0 | 12/31/2022 |
0.14622 % | Morgan Stanley Smith Barney LLC | 70,221 | 0 | 12/31/2022 |
0.12513 % | BG Fund Management Luxembourg S.A. | 60,092 | 0 | 12/31/2022 |
0.12202 % | Kensington Investment Counsel, LLC | 58,599 | -18,202 | 12/31/2022 |
0.10229 % | RBF Capital, LLC | 49,122 | -15,781 | 12/31/2022 |
0.09816 % | Qube Research & Technologies Ltd | 47,137 | 13,399 | 12/31/2022 |
0.09614 % | Cubist Systematic Strategies, LLC | 46,167 | -26,901 | 12/31/2022 |
0.08168 % | Aldrich (Richard H) | 39,226 | -358,500 | 3/6/2023 |
0.08057 % | Cassella (James V) | 38,690 | -3,762 | 2/15/2023 |
0.07925 % | 683 Capital Management LLC | 38,058 | 38,058 | 12/31/2022 |
0.07689 % | van Heek (Christine) | 36,926 | 26,926 | 6/9/2022 |
0.07371 % | Lake Street Advisors | 35,398 | 0 | 12/31/2022 |
0.06771 % | Alps Advisors, Inc. | 32,516 | 6,319 | 12/31/2022 |
0.06395 % | BlackRock Advisors (UK) Limited | 30,710 | 8,243 | 2/28/2023 |
0.06247 % | ACCI Capital Investments SGIIC, SA | 30,000 | -10,000 | 12/31/2022 |
0.06123 % | Jane Street Capital, L.L.C. | 29,404 | 18,992 | 12/31/2022 |
0.06084 % | Dimensional Fund Advisors, Ltd. | 29,215 | 4,867 | 1/31/2023 |
0.06045 % | Marshall Wace LLP | 29,030 | 29,030 | 12/31/2022 |
0.06018 % | Auchincloss (Thomas G Jr) | 28,900 | 22,400 | 6/9/2022 |
0.05875 % | Apo Asset Management GmbH | 28,215 | 0 | 1/31/2023 |
0.05411 % | AHL Partners LLP | 25,987 | 25,987 | 12/31/2022 |
0.05085 % | Occudo Quantitative Strategies LP | 24,418 | -38,386 | 12/31/2022 |
0.05073 % | Hutt (Peter Barton) | 24,363 | 0 | 10/14/2022 |
0.05052 % | BlackRock Financial Management, Inc. | 24,259 | 8,692 | 12/31/2022 |
0.04963 % | Barclays Capital Inc. | 23,835 | 21,314 | 12/31/2022 |
0.04720 % | BlackRock Asset Management Ireland Limited | 22,668 | 22,668 | 12/31/2022 |
0.04334 % | Northern Trust Global Investments | 20,813 | -5 | 12/31/2022 |
0.04320 % | Lighthouse Partners | 20,746 | 20,746 | 12/31/2022 |
0.04240 % | SG Americas Securities, L.L.C. | 20,361 | 3,352 | 12/31/2022 |
0.04165 % | Birchview Capital, LP | 20,000 | 0 | 12/31/2022 |
0.03834 % | Boothbay Fund Management, LLC | 18,414 | 18,414 | 12/31/2022 |
0.03830 % | Becker (Marc A) | 18,392 | -3,762 | 2/15/2023 |
0.03598 % | BNY Mellon Asset Management | 17,278 | 0 | 12/31/2022 |
0.03540 % | Alpine Associates Management Inc. | 17,000 | -17,700 | 2/28/2023 |
0.03415 % | Hoeiland (Jesper) | 16,400 | 16,400 | 6/9/2022 |
0.03415 % | Jaeger (Wilfred E) | 16,400 | 16,400 | 6/9/2022 |
0.03290 % | Acuitas Investments LLC | 15,800 | -600 | 12/31/2022 |
0.03266 % | Charles Schwab Investment Management, Inc. | 15,686 | 0 | 12/31/2022 |
0.03242 % | HSBC Global Asset Management (UK) Limited | 15,571 | 0 | 12/31/2022 |
0.03209 % | Tung (Roger D) | 15,411 | -814,343 | 3/6/2023 |
0.03209 % | Mirabella Financial Services LLP | 15,410 | 15,410 | 12/31/2022 |
0.03002 % | Jump Financial, LLC | 14,418 | -21,782 | 12/31/2022 |
0.02499 % | Cantor Fitzgerald, L.P | 12,000 | -30,100 | 12/31/2022 |
0.02155 % | Flagship Harbor Advisors LLC | 10,350 | 0 | 12/31/2022 |
0.02082 % | Roanoke Asset Management Corp. | 10,000 | 0 | 12/31/2022 |
0.02041 % | Blackstone Alternative Investment Advisors LLC | 9,800 | 8,000 | 9/30/2022 |
0.01664 % | Lord, Abbett & Co. LLC | 7,992 | 0 | 1/31/2023 |
0.01664 % | BlackRock Investment Management, LLC | 7,992 | 242 | 12/31/2022 |
0.01541 % | Tower Research Capital LLC | 7,398 | 5,351 | 12/31/2022 |
0.01520 % | UBS Financial Services, Inc. | 7,301 | -6,560 | 12/31/2022 |