10.25535 % | The Vanguard Group, Inc. | 7,052,605 | 56,561 | 12/31/2024 |
9.78114 % | EcoR1 Capital, LLC | 6,726,491 | 0 | 12/31/2024 |
7.68529 % | BlackRock Institutional Trust Company, N.A. | 5,285,175 | 152,309 | 12/31/2024 |
5.85132 % | T. Rowe Price Associates, Inc. | 4,023,951 | 289,365 | 12/31/2024 |
5.06053 % | Citadel Advisors LLC | 3,480,125 | 407,457 | 1/30/2025 |
5.02809 % | Pfizer Inc | 3,457,815 | 0 | 12/31/2024 |
4.84849 % | RTW Investments L.P. | 3,334,308 | 551,979 | 12/31/2024 |
3.47477 % | Bellevue Asset Management AG | 2,389,600 | 3,000 | 12/31/2024 |
3.21104 % | T. Rowe Price Investment Management, Inc. | 2,208,234 | 2,208,234 | 12/31/2024 |
2.92818 % | UBS Financial Services, Inc. | 2,013,709 | 1,544,844 | 12/31/2024 |
2.58333 % | ArrowMark Colorado Holdings, LLC | 1,776,555 | 532,105 | 12/31/2024 |
2.38047 % | State Street Global Advisors (US) | 1,637,050 | -6,677 | 12/31/2024 |
2.36295 % | Opaleye Management Inc. | 1,625,000 | 370,000 | 12/31/2024 |
2.30583 % | New Leaf Venture Partners LLC | 1,585,721 | 151,000 | 12/31/2024 |
2.19720 % | Geode Capital Management, L.L.C. | 1,511,014 | -8,320 | 12/31/2024 |
2.04798 % | Nextech Invest, Ltd. | 1,408,394 | 0 | 12/31/2024 |
1.97470 % | Avidity Partners Management LP | 1,358,000 | -139,000 | 12/31/2024 |
1.93799 % | JP Morgan Asset Management | 1,332,753 | -149,928 | 12/31/2024 |
1.80874 % | Norges Bank Investment Management (NBIM) | 1,243,868 | 165,622 | 12/31/2024 |
1.53935 % | Boxer Capital Management, LLC | 1,058,614 | 1,058,614 | 12/31/2024 |
1.25891 % | Houston (John G) | 865,750 | -188,441 | 3/31/2024 |
1.25277 % | Fidelity Institutional Asset Management | 861,530 | -587,912 | 12/31/2024 |
1.24783 % | Morgan Stanley & Co. LLC | 858,133 | 446,418 | 12/31/2024 |
1.22645 % | Dimensional Fund Advisors, L.P. | 843,430 | 186,254 | 12/31/2024 |
1.07714 % | Perceptive Advisors LLC | 740,749 | -287,000 | 12/31/2024 |
1.03792 % | Finepoint Capital LP | 713,778 | 139,400 | 12/31/2024 |
1.01789 % | Logos Global Management LLC | 700,000 | 300,000 | 12/31/2024 |
1.01396 % | Fidelity Management & Research Company LLC | 697,297 | -736,865 | 12/31/2024 |
1.00732 % | Woodline Partners LP | 692,733 | 194,996 | 12/31/2024 |
1.00080 % | BlackRock Financial Management, Inc. | 688,250 | -43,816 | 12/31/2024 |
0.98895 % | Two Sigma Investments, LP | 680,102 | 66,233 | 12/31/2024 |
0.95405 % | Schonfeld Strategic Advisors LLC | 656,100 | 300,295 | 12/31/2024 |
0.94925 % | Candriam Luxembourg S.A. | 652,801 | 0 | 12/31/2024 |
0.91610 % | Affinity Asset Advisors LLC | 630,000 | 405,000 | 12/31/2024 |
0.81866 % | Northern Trust Investments, Inc. | 562,995 | 55,788 | 12/31/2024 |
0.77957 % | Charles Schwab Investment Management, Inc. | 536,112 | 5,443 | 12/31/2024 |
0.73278 % | Candriam Belgium S.A. | 503,936 | -20,845 | 12/31/2024 |
0.63435 % | Wasatch Global Investors Inc | 436,241 | 298 | 12/31/2024 |
0.61269 % | RA Capital Management, LP | 421,348 | 0 | 12/31/2024 |
0.58976 % | Baker Bros. Advisors LP | 405,576 | 0 | 12/31/2024 |
0.53155 % | Goldman Sachs & Company, Inc. | 365,546 | -215,269 | 12/31/2024 |
0.47807 % | Aquilo Capital Management, LLC | 328,766 | -60,000 | 12/31/2024 |
0.45782 % | Millennium Management LLC | 314,843 | 106,218 | 12/31/2024 |
0.43214 % | PanAgora Asset Management Inc. | 297,186 | 35,475 | 12/31/2024 |
0.41491 % | Frazier Life Sciences Management, L.P. | 285,331 | 0 | 9/30/2024 |
0.38974 % | Marshall Wace LLP | 268,026 | 97,676 | 12/31/2024 |
0.38320 % | BIT Capital GmbH | 263,527 | 196,246 | 12/31/2024 |
0.36874 % | UBS Asset Management (Switzerland) | 253,584 | 208,703 | 12/31/2024 |
0.36743 % | American Century Investment Management, Inc. | 252,685 | -58,788 | 12/31/2024 |
0.36355 % | J.P. Morgan Securities LLC | 250,010 | 98,722 | 12/31/2024 |
0.33928 % | BlackRock Advisors (UK) Limited | 233,323 | 758 | 1/31/2025 |
0.33864 % | Nordea Funds Oy | 232,886 | 9,196 | 12/31/2024 |
0.32238 % | Nuveen LLC | 221,698 | -1,725 | 12/31/2024 |
0.32067 % | BlackRock Asset Management Ireland Limited | 220,528 | 17,495 | 12/31/2024 |
0.31802 % | Exome Asset Management LLC | 218,700 | 218,700 | 12/31/2024 |
0.30776 % | Nordea Investment Management AB (Denmark) | 211,644 | -3,141 | 12/31/2024 |
0.30390 % | Kennedy Capital Management LLC | 208,992 | 61,802 | 12/31/2024 |
0.30257 % | BlackRock Investment Management, LLC | 208,079 | -39,930 | 12/31/2024 |
0.30088 % | Caption Management, LLC | 206,915 | 206,915 | 12/31/2024 |
0.29953 % | Algert Global LLC | 205,988 | 37,927 | 12/31/2024 |
0.27133 % | Gilder Gagnon Howe & Co. LLC | 186,594 | -7,749 | 12/31/2024 |
0.26994 % | UBS Asset Management Switzerland AG | 185,641 | 0 | 1/31/2025 |
0.25450 % | Barclays Bank PLC | 175,019 | 53,320 | 12/31/2024 |
0.24367 % | Cassidy (Sean A) | 167,572 | -19,135 | 3/31/2024 |
0.23905 % | Neuberger Berman, LLC | 164,392 | 5,762 | 12/31/2024 |
0.23864 % | TwinBeech Capital LP | 164,112 | 164,112 | 12/31/2024 |
0.22612 % | Rhenman & Partners Asset Management AB | 155,500 | 25,000 | 12/31/2024 |
0.21085 % | Ghost Tree Capital, LLC | 145,000 | 70,000 | 9/30/2024 |
0.20594 % | JPMorgan Asset Management U.K. Limited | 141,626 | -478,697 | 12/31/2024 |
0.20433 % | Assenagon Asset Management S.A. | 140,518 | 777 | 12/31/2024 |
0.18723 % | BofA Global Research (US) | 128,755 | -315,298 | 12/31/2024 |
0.18598 % | SELECTRA Management Company S.A. | 127,900 | 1,900 | 6/30/2024 |
0.18510 % | Goldman Sachs Asset Management, L.P. | 127,292 | -46,019 | 12/31/2024 |
0.17791 % | TD Asset Management Inc. | 122,348 | 48,800 | 12/31/2024 |
0.17126 % | BNY Mellon Asset Management | 117,776 | -3,869 | 12/31/2024 |
0.16942 % | Columbia Threadneedle Investments (US) | 116,513 | 19,505 | 12/31/2024 |
0.16320 % | Parametric Portfolio Associates LLC | 112,231 | 8,666 | 12/31/2024 |
0.16100 % | Jane Street Capital, L.L.C. | 110,722 | -26,573 | 12/31/2024 |
0.16085 % | Banque Pictet & Cie S.A. | 110,619 | -10,205 | 12/31/2024 |
0.15540 % | Parkman Healthcare Partners LLC | 106,871 | 10,688 | 12/31/2024 |
0.14541 % | Saint Olive Gestion | 100,000 | 0 | 12/31/2024 |
0.14541 % | Wanjia Asset Management Co., Ltd. | 100,000 | -50,000 | 6/30/2024 |
0.14541 % | DWS Investment GmbH | 100,000 | 0 | 12/31/2024 |
0.14342 % | BlackRock Investment Management (UK) Ltd. | 98,629 | -9,752 | 12/31/2024 |
0.13669 % | Schweizerische Nationalbank | 94,000 | 0 | 12/31/2024 |
0.13665 % | UBS Asset Management (Americas), Inc. | 93,977 | -22,527 | 12/31/2024 |
0.13658 % | Taylor (Ian) | 93,928 | -56,279 | 3/31/2024 |
0.13214 % | Nomura Asset Management Taiwan Limited | 90,870 | 0 | 12/31/2024 |
0.13020 % | Manulife Investment Management (North America) Limited | 89,540 | -866 | 12/31/2024 |
0.12779 % | Graham Capital Management, L.P. | 87,879 | 24,303 | 12/31/2024 |
0.12778 % | Rhumbline Advisers Ltd. Partnership | 87,877 | 754 | 12/31/2024 |
0.12597 % | Patient Square Capital, LP | 86,627 | 86,627 | 12/31/2024 |
0.12571 % | Zacks Investment Management, Inc. | 86,448 | -3,379 | 12/31/2024 |
0.11724 % | DWS Investments UK Limited | 80,625 | -13,166 | 12/31/2024 |
0.11633 % | Edmond de Rothschild Asset Management (France) S.A. | 80,000 | 80,000 | 12/31/2024 |
0.11496 % | T. Rowe Price International Ltd | 79,060 | -40,070 | 12/31/2024 |
0.11427 % | abrdn Inc. | 78,585 | 0 | 12/31/2024 |
0.11080 % | Qube Research & Technologies Ltd | 76,198 | -133,711 | 12/31/2024 |
0.10855 % | Engineers Gate Manager, L.P. | 74,651 | 44,919 | 12/31/2024 |
0.10780 % | JPMorgan Private Bank (United States) | 74,133 | -878 | 12/31/2024 |