٩٫١٧٥٥٥ % | EcoR1 Capital, LLC | ١١٬١٧٣٬٠٦٨ | ٢٧٣٬٢٠٩ | ٣١/١٢/٢٠٢٣ |
٩٫١٢٤٦٧ % | Avoro Capital Advisors LLC | ١١٬١١١٬١١١ | 0 | ٣١/١٢/٢٠٢٣ |
٧٫٨٣٢٥٧ % | The Vanguard Group, Inc. | ٩٬٥٣٧٬٧١٩ | ٨٥٬٧٠١ | ٣١/١٢/٢٠٢٣ |
٥٫١٧٦٦٣ % | T. Rowe Price Investment Management, Inc. | ٦٬٣٠٣٬٥٨٤ | -٢١٥٬٨٨٧ | ٣١/١٢/٢٠٢٣ |
٣٫٩٦٨٨٦ % | BlackRock Institutional Trust Company, N.A. | ٤٬٨٣٢٬٨٧٧ | ٩٢٬٧١٧ | ٣١/١٢/٢٠٢٣ |
٢٫٦٩٠٢٥ % | Jennison Associates LLC | ٣٬٢٧٥٬٩٢٢ | -٢٦٦٬٢٨٧ | ٣١/١٢/٢٠٢٣ |
٢٫٣٩٤٢٠ % | State Street Global Advisors (US) | ٢٬٩١٥٬٤٢٢ | -٣٢٢٬٦٩٢ | ٣١/١٢/٢٠٢٣ |
٢٫٣٠٥١٥ % | Octagon Capital Advisors LP | ٢٬٨٠٦٬٩٨٠ | -٣٢٣٬٠٢٠ | ٣١/١٢/٢٠٢٣ |
٢٫٢٩٥٥١ % | Morgan Stanley & Co. LLC | ٢٬٧٩٥٬٢٤٠ | ١٬٦٠١٬٥٤٢ | ٣١/١٢/٢٠٢٣ |
١٫٩٦٩٩٨ % | T. Rowe Price Associates, Inc. | ٢٬٣٩٨٬٨٤٢ | ٦٦٩٬٧٥٩ | ٣١/١٢/٢٠٢٣ |
١٫٧٦١٥٢ % | Assenagon Asset Management S.A. | ٢٬١٤٥٬٠٠٤ | ١٬١٢١٬٤٩٧ | ٣١/١٢/٢٠٢٣ |
١٫٧١٨٣٧ % | Fidelity Management & Research Company LLC | ٢٬٠٩٢٬٤٦٤ | -١٦٧٬٠٨٦ | ٣١/١٢/٢٠٢٣ |
١٫٤١٧٤٣ % | Boxer Capital, L.L.C. | ١٬٧٢٦٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٤٠٩٢٧ % | JP Morgan Asset Management | ١٬٧١٦٬٠٧٠ | ٧٠٬١٣٤ | ٣١/١٢/٢٠٢٣ |
١٫٣٣٩١٢ % | Geode Capital Management, L.L.C. | ١٬٦٣٠٬٦٤٢ | ٧٥٬٨١٦ | ٣١/١٢/٢٠٢٣ |
١٫١٦٧٢٤ % | Invus Public Equities Advisors, LLC | ١٬٤٢١٬٣٤٦ | -٢٤٣٬٢٢٦ | ٣١/١٢/٢٠٢٣ |
١٫١٠٤١٨ % | Pictet Asset Management Ltd. | ١٬٣٤٤٬٥٦٣ | ٦١٠٬٤١٣ | ٣١/١٢/٢٠٢٣ |
١٣٫٥٠٥٢١ % | Wellington Management Company, LLP | ١٦٬٤٤٥٬٢٩٠ | ١٬٢٧٨٬٢٤٦ | ٣١/١٢/٢٠٢٣ |
١٠٫٥١٦٨٣ % | Morningside Venture Investments, Ltd. | ١٢٬٨٠٦٬٣٤٢ | 0 | ٣١/٣/٢٠٢٣ |
٠٫٨٧٣٢٠ % | Deschatelets (Pascal) | ١٬٠٦٣٬٣٠١ | 0 | ٨/٤/٢٠٢٤ |
٠٫٨٦٥١١ % | Polar Capital LLP | ١٬٠٥٣٬٤٤٠ | -٤٣٥ | ٣١/١٢/٢٠٢٣ |
٠٫٧٨٠١٦ % | Logos Global Management LLC | ٩٥٠٬٠٠٠ | ٢٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٧٧٧٠٥ % | Norges Bank Investment Management (NBIM) | ٩٤٦٬٢١٣ | -١٠١٬٢٤١ | ٣١/١٢/٢٠٢٣ |
٠٫٧٥٧٣٣ % | OrbiMed Advisors, LLC | ٩٢٢٬٢٠٠ | -٣٣٨٬٣٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٧٥٤٧٨ % | Fiera Capital Corporation | ٩١٩٬٠٩٠ | -٦٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٧٤٢٧٢ % | Charles Schwab Investment Management, Inc. | ٩٠٤٬٤٠٩ | ٢٥٬٠٥٢ | ٣١/١٢/٢٠٢٣ |
٠٫٧٢٦٩٢ % | Frazier Healthcare Partners | ٨٨٥٬١٦٥ | ٢٧١٬١٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫٦٧٤٨٨ % | Bellevue Asset Management AG | ٨٢١٬٨٠٠ | ٢٧٬٩٥٩ | ٣١/١٢/٢٠٢٣ |
٠٫٦٣٩٦٠ % | Machiels (Alec) | ٧٧٨٬٨٤٤ | ٣٬٣٤١ | ١/١/٢٠٢٤ |
٠٫٥٣٦٦٠ % | Francois (Cedric G) | ٦٥٣٬٤١٨ | 0 | ١/٣/٢٠٢٤ |
٠٫٥١٣٢٦ % | Cormorant Asset Management, LP | ٦٢٥٬٠٠٠ | -١٬٣٧٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٠٦١٠ % | Victory Capital Management Inc. | ٦١٦٬٢٧٢ | -١٢٢٬٢٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫٥٠٢٤٦ % | JPMorgan Asset Management U.K. Limited | ٦١١٬٨٤٠ | ١٣٧٬١٤٥ | ٣١/١٢/٢٠٢٣ |
٠٫٤٧٩١٢ % | Macquarie Investment Management | ٥٨٣٬٤٢٩ | -٤٩٣٬١١٩ | ٣١/١٢/٢٠٢٣ |
٠٫٤٠٦٢٧ % | Invesco Advisers, Inc. | ٤٩٤٬٧٠٩ | ٢٬٥٩٧ | ٣١/١٢/٢٠٢٣ |
٠٫٤٠٢٠١ % | Columbia Threadneedle Investments (US) | ٤٨٩٬٥٢٢ | ٢١٣٬١٨٨ | ٣١/١٢/٢٠٢٣ |
٠٫٣٩٦٩١ % | TD Asset Management Inc. | ٤٨٣٬٣٢٢ | ١١٢٬٤٦٥ | ٣١/١٢/٢٠٢٣ |
٠٫٣٩٥٤٢ % | Driehaus Capital Management, LLC | ٤٨١٬٥٠١ | ٣٠٠٬١٧٧ | ٣١/١٢/٢٠٢٣ |
٠٫٣٨١٤٦ % | Candriam Luxembourg S.A. | ٤٦٤٬٥٠٧ | ٩٥٬٠٠٠ | ٢٩/٢/٢٠٢٤ |
٠٫٣٦٦٢٦ % | Eagle Asset Management, Inc. | ٤٤٦٬٠٠٠ | -٣٬٩٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥٦٩٩ % | Jane Street Capital, L.L.C. | ٤٣٤٬٧٠١ | ١٦١٬٤٧٥ | ٣١/١٢/٢٠٢٣ |
٠٫٣٣٠٢٨ % | Dunlop (Sinclair Andrew) | ٤٠٢٬١٨٥ | ١٬٥٠٠ | ١٢/٤/٢٠٢٤ |
٠٫٣٢٢٧٧ % | Caption Management, LLC | ٣٩٣٬٠٣١ | ١١٩٬٧٨١ | ٣١/١٢/٢٠٢٣ |
٠٫٣١٨٣٤ % | Northern Trust Investments, Inc. | ٣٨٧٬٦٤٣ | ١٨٬٢٩٢ | ٣١/١٢/٢٠٢٣ |
٠٫٣١٤٣٩ % | Susquehanna International Group, LLP | ٣٨٢٬٨٣٢ | ١٠٬٠٤٧ | ٣١/١٢/٢٠٢٣ |
٠٫٣٠٢٦٣ % | BMO Capital Markets (US) | ٣٦٨٬٥١٠ | -٦٢٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٩٥٥٨ % | DWS Investments UK Limited | ٣٥٩٬٩٢٨ | ٣٥٦٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧٩٦٣ % | New York State Common Retirement Fund | ٣٤٠٬٥٠٧ | -٦٢٬٤٣٧ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧٧١٧ % | Candriam Belgium S.A. | ٣٣٧٬٥٠٧ | ١١٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦٦٠٨ % | PGIM Securities Investment Trust Enterprise | ٣٢٤٬٠٠٠ | ٢٣٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣٤١٤ % | Citadel Advisors LLC | ٢٨٥٬١١٧ | ٢٧٠٬٣٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣١٨٨ % | Medical Strategy GmbH | ٢٨٢٬٣٦٥ | -٦٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٩٠٥ % | Nuveen LLC | ٢٦٦٬٧٣٩ | -٦٬٤٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫٢١٠٦٧ % | Voya Investment Management LLC | ٢٥٦٬٥٣٣ | ١٧٤٬٣٦٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠٨٥١ % | Group One Trading, L.P. | ٢٥٣٬٩٠٥ | ٢٧٬٢٢١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠١٦٦ % | Ensign Peak Advisors, Inc. | ٢٤٥٬٥٦٦ | ٦٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٩٢٣ % | Fiduciary Trust Company | ٢٤٢٬٦٠٧ | -٢٢٬٦٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٩٨٢٢ % | Amundi Asset Management US, Inc. | ٢٤١٬٣٧١ | ١٣٥٬٣١٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٨٩٦٠ % | Marshall Wace LLP | ٢٣٠٬٨٧٦ | ٦١٬٥٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٨٨٥٧ % | Franklin Advisers, Inc. | ٢٢٩٬٦٢٢ | ٢٢٩٬٦٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٧٢٢٩ % | Eventide Asset Management, LLC | ٢٠٩٬٧٩٤ | ٢٠٩٬٧٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٧٠٩٥ % | Great Lakes Advisors, LLC | ٢٠٨٬١٦٣ | ٢٠٨٬١٦٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٦٥٦٩ % | Managed Account Advisors LLC | ٢٠١٬٧٦٤ | -١٣٨٬٢٦٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٩٩٨ % | Barclays Bank PLC | ١٩٤٬٨١٣ | -١٣٣٬٠٠٨ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٧٢٢ % | Goldman Sachs Asset Management, L.P. | ١٩١٬٤٤٩ | -٣١٬٣٨٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٦٧٦ % | DWS Investment S.A. | ١٩٠٬٨٨٩ | ١٩٠٬٨٨٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٤٧٩ % | DWS Investment GmbH | ١٨٨٬٤٩٣ | -١٥٬٥٧٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٣٧٤ % | BNY Mellon Asset Management | ١٨٧٬٢١٠ | ٣٬٨٢٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٥٢٩٣ % | Woodline Partners LP | ١٨٦٬٢٢٤ | ١٨٦٬٢٢٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٥١٦٠ % | BlackRock Financial Management, Inc. | ١٨٤٬٦٠٥ | -٣٤٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٤٢٢٧ % | Tekla Capital Management LLC_NLE | ١٧٣٬٢٤٨ | ٣٨٬١٢٤ | ٣٠/٦/٢٠٢٣ |
٠٫١٣٨٨٣ % | abrdn Inc. | ١٦٩٬٠٥١ | ١٦٩٬٠٥١ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٧٥٤ % | BNP Paribas Securities Corp. North America | ١٦٧٬٤٨٨ | -٦٨٬٨٦٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٤٤٣ % | Mellon Investments Corporation | ١٦٣٬٦٩٤ | -٢٬٣٨٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٣٣٣٧ % | Schweizerische Nationalbank | ١٦٢٬٤٠٠ | -١٦٬٨٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٤٩٩ % | Altitude Crest Partners Inc | ١٥٢٬٢٠٠ | ١٥٢٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٤٤٠ % | Morgan Stanley Smith Barney LLC | ١٥١٬٤٨٣ | -١٢٠٬٣٥١ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٣٤٣ % | BlackRock Asset Management Ireland Limited | ١٥٠٬٣٠١ | ٤٬٩٢٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٢٣١٨ % | Ally Bridge Group NY LLC | ١٥٠٬٠٠٠ | -٣١٬٨٠٥ | ٣١/١٢/٢٠٢٣ |
٠٫١٢١٢٧ % | Walleye Capital LLC | ١٤٧٬٦٧٤ | ١٣٬٦٩١ | ٣١/١٢/٢٠٢٣ |
٠٫١١٩٧٦ % | California Public Employees' Retirement System | ١٤٥٬٨٣٣ | -٣٨٬٠١١ | ٣١/١٢/٢٠٢٣ |
٠٫١١٩٣٦ % | J.P. Morgan Securities plc | ١٤٥٬٣٤٢ | ١٤٥٬٣٤٢ | ٣١/١٢/٢٠٢٣ |
٠٫١١٧٥٣ % | Rafferty Asset Management LLC | ١٤٣٬١١٨ | -٧١٬٠٤٣ | ٣١/١٢/٢٠٢٣ |
٠٫١١٧٣٧ % | Saturn V Capital Management LLC | ١٤٢٬٩٢٧ | ١٤٢٬٩٢٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٩٧٠ % | Rhumbline Advisers Ltd. Partnership | ١٣٣٬٥٨٦ | ١٬٢٩٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٧٩١ % | Pictet Asset Management (Japan) Ltd. | ١٣١٬٤٠٤ | ١٣١٬٤٠٤ | ٣١/١٠/٢٠٢٣ |
٠٫١٠٧٦٦ % | Lombard Odier Asset Management (Europe) Ltd | ١٣١٬٠٩٨ | -٣٨٬٩٥٦ | ٣٠/٩/٢٠٢٢ |
٠٫١٠٦٧٦ % | 683 Capital Management LLC | ١٣٠٬٠٠٠ | -١١٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٠٢٨٢ % | Wells Fargo Advisors | ١٢٥٬٢٠٦ | ١٥٬٣٠٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٨٢٦ % | PNC Investments LLC | ١١٩٬٦٥٣ | ٥٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٧٧٤ % | BofA Global Research (US) | ١١٩٬٠١٧ | -٢٤٥٬٩١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٤٨١ % | Allspring Global Investments, LLC | ١١٥٬٤٥٣ | ٥٦٬١٧٨ | ٣١/٣/٢٠٢٤ |
٠٫٠٩٤٢٨ % | Goldman Sachs & Company, Inc. | ١١٤٬٨١٠ | ٥٬٨٥٣ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩٣٦٨ % | LMR Partners LLP | ١١٤٬٠٦٩ | ٥٦٬٩٤٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٨٦٩ % | Cutter Capital Management, LP | ١٠٨٬٠٠٠ | ١٠٨٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٧٠٥ % | Manulife Investment Management (North America) Limited | ١٠٦٬٠٠٢ | ٥١٬٧٣٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٢٧٤ % | Parametric Portfolio Associates LLC | ١٠٠٬٧٥٢ | ١٤٬٥٦٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٢٤٥ % | Rhenman & Partners Asset Management AB | ١٠٠٬٤٠٠ | -١١٤٬٦٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨١٩٦ % | BMO Nesbitt Burns Inc. | ٩٩٬٨٠٠ | ٩٩٬٨٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨٠٢٥ % | Thrivent Asset Management, LLC | ٩٧٬٧١٦ | ١٨٬٢٥٥ | ٣١/١٢/٢٠٢٣ |