| 14,98494 % | Fidelity Management & Research Company LLC | 13.137.294 | 7.067 | |
| 7,61033 % | BlackRock Institutional Trust Company, N.A. | 6.671.979 | -480.565 | |
| 7,47427 % | Capital Research Global Investors | 6.552.691 | 3.817.768 | |
| 7,07909 % | Janus Henderson Investors | 6.206.238 | -195.543 | |
| 6,69510 % | Capital World Investors | 5.869.591 | 0 | |
| 5,73546 % | Point72 Asset Management, L.P. | 5.028.279 | 4.888.154 | |
| 5,61651 % | The Vanguard Group, Inc. | 4.923.996 | -152.936 | |
| 5,27805 % | Federated Hermes Global Investment Management Corp. | 4.627.266 | -140.660 | |
| 4,46596 % | Deerfield Management Company, L.P. | 3.915.311 | 647.760 | |
| 3,86198 % | State Street Investment Management (US) | 3.385.794 | -60.436 | |
| 3,81544 % | Logos Global Management LP | 3.345.000 | -155.000 | |
| 2,44986 % | Sofinnova Investments, Inc | 2.147.795 | -474.397 | |
| 2,41671 % | Baker Bros. Advisors LP | 2.118.728 | 1.056.605 | |
| 2,41036 % | Geode Capital Management, L.L.C. | 2.113.164 | 33.286 | |
| 2,08270 % | Citadel Advisors LLC | 1.825.903 | 320.823 | |
| 2,07053 % | T. Rowe Price Associates, Inc. | 1.815.238 | -1.575.049 | |
| 2,05901 % | Pictet Asset Management Ltd. | 1.805.136 | -33.628 | |
| 1,70022 % | Fiera Capital Inc. | 1.490.586 | 312.230 | |
| 1,41222 % | Adage Capital Management, L.P. | 1.238.094 | 50.000 | |
| 1,31769 % | Candriam Luxembourg S.A. | 1.155.215 | 4.313 | |
| 1,30949 % | Morgan Stanley & Co. LLC | 1.148.029 | -118.204 | |
| 1,27671 % | Goldman Sachs & Company, Inc. | 1.119.289 | 379.816 | |
| 1,15615 % | BlackRock Financial Management, Inc. | 1.013.600 | -26.182 | |
| 1,05178 % | Fisher Investments | 922.092 | -42.939 | |
| 1,04300 % | Candriam Belgium S.A. | 914.400 | -23.777 | |
| 0,88040 % | Eventide Asset Management, LLC | 771.844 | 0 | |
| 0,85708 % | UBS Financial Services, Inc. | 751.400 | 308.693 | |
| 0,84617 % | Ensign Peak Advisors, Inc. | 741.833 | 414.189 | |
| 0,81761 % | Charles Schwab Investment Management, Inc. | 716.798 | 13.082 | |
| 0,78784 % | Hata (Yujiro S.) | 690.695 | 0 | |
| 0,74369 % | Northern Trust Investments, Inc. | 651.994 | -45.618 | |
| 0,72524 % | BofA Global Research (US) | 635.819 | -328.093 | |
| 0,70616 % | Dafna Capital Management, LLC | 619.090 | 29.760 | |
| 0,59984 % | Qube Research & Technologies Ltd | 525.878 | -463.457 | |
| 0,58302 % | Rosalind Advisors, Inc. | 511.132 | -188.868 | |
| 0,50788 % | Two Sigma Investments, LP | 445.261 | -436.917 | |
| 0,50337 % | abrdn Inc. | 441.305 | 0 | |
| 0,49332 % | Redmile Group, LLC | 432.494 | -102.106 | |
| 0,46501 % | BNP Paribas Asset Management USA, Inc. | 407.671 | 39.915 | |
| 0,45819 % | New York State Common Retirement Fund | 401.692 | 70.620 | |
| 0,45569 % | BlackRock Investment Management, LLC | 399.505 | 68.132 | |
| 0,37019 % | AXA Investment Managers UK Ltd. | 324.543 | 523 | |
| 0,36355 % | Barclays Bank PLC | 318.720 | 136.596 | |
| 0,34571 % | BlackRock Advisors (UK) Limited | 303.084 | 1.806 | |
| 0,34210 % | Parametric Portfolio Associates LLC | 299.919 | 45.796 | |
| 0,32837 % | Managed Account Advisors LLC | 287.886 | 66.612 | |
| 0,32373 % | Voloridge Investment Management, LLC | 283.811 | -9.764 | |
| 0,32160 % | BlackRock Asset Management Ireland Limited | 281.947 | 27.891 | |
| 0,31968 % | General American Investors Company, Inc. | 280.261 | 20.000 | |
| 0,30796 % | Aperio Group, LLC | 269.985 | 82.894 | |
| 0,30335 % | J.P. Morgan Securities LLC | 265.951 | 27.229 | |
| 0,28867 % | Algert Global LLC | 253.080 | -53.628 | |
| 0,28516 % | Soleus Capital Management, L.P. | 250.000 | 250.000 | |
| 0,27346 % | WCM Investment Management | 239.738 | -4.343 | |
| 0,25823 % | Woodline Partners LP | 226.390 | -88.982 | |
| 0,25203 % | Schroder Investment Management Ltd. (SIM) | 220.952 | -41.654 | |
| 0,25094 % | DWS Investment GmbH | 220.000 | 37.125 | |
| 0,24446 % | Nuveen LLC | 214.317 | -69.994 | |
| 0,23902 % | Schonfeld Strategic Advisors LLC | 209.551 | 209.551 | |
| 0,23635 % | SummitTX Capital, L.P. | 207.209 | 74.786 | |
| 0,22288 % | DWS Investments UK Limited | 195.399 | -87.445 | |
| 0,21200 % | UBS Asset Management (Switzerland) | 185.864 | 95.004 | |
| 0,19774 % | BlackRock Investment Management (UK) Ltd. | 173.359 | 20.505 | |
| 0,19468 % | Dimensional Fund Advisors, L.P. | 170.672 | 89.475 | |
| 0,19039 % | Platinum Asset Management | 166.917 | 14.204 | |
| 0,18922 % | StemPoint Capital LP | 165.885 | 98.886 | |
| 0,18634 % | Wells Fargo Advisors | 163.363 | 35.299 | |
| 0,17685 % | BNY Mellon Asset Management | 155.046 | 2.451 | |
| 0,17201 % | Schweizerische Nationalbank | 150.800 | 0 | |
| 0,17024 % | RBC Capital Markets Wealth Management | 149.251 | 31.343 | |
| 0,16479 % | Foresite Capital Management, LLC | 144.468 | 144.468 | |
| 0,16419 % | Susquehanna International Group, LLP | 143.945 | 14.210 | |
| 0,14959 % | Rhumbline Advisers Ltd. Partnership | 131.149 | 6.712 | |
| 0,14589 % | Nomura Asset Management Co., Ltd. | 127.900 | 83.200 | |
| 0,14170 % | Sio Capital Management, LLC | 124.230 | 1.230 | |
| 0,13880 % | Creative Planning, Inc. | 121.684 | 60.667 | |
| 0,13077 % | American Century Investment Management, Inc. | 114.644 | 102.736 | |
| 0,12525 % | Rafferty Asset Management LLC | 109.807 | -11.581 | |
| 0,12451 % | Envestnet Asset Management, Inc. | 109.155 | 11.752 | |
| 0,12421 % | Goldman Sachs Asset Management, L.P. | 108.895 | 32.146 | |
| 0,11501 % | New Jersey Division of Investment | 100.827 | 10.047 | |
| 0,11196 % | D. E. Shaw & Co., L.P. | 98.153 | -210.403 | |
| 0,11159 % | AllianceBernstein L.P. | 97.830 | 0 | |
| 0,11087 % | J.P. Morgan Mansart Management Limited | 97.200 | 97.200 | |
| 0,10885 % | Crestline Investors, Inc. | 95.428 | 70.571 | |
| 0,10323 % | Mellon Investments Corporation | 90.498 | 23.018 | |
| 0,10229 % | T. Rowe Price International Ltd | 89.678 | 4.343 | |
| 0,09801 % | Legal & General Investment Management Ltd. | 85.923 | 1.234 | |
| 0,09716 % | Aquatic Capital Management LLC | 85.178 | 36.551 | |
| 0,09500 % | Victory Capital Management Inc. | 83.288 | 39.988 | |
| 0,09414 % | California State Teachers Retirement System | 82.532 | 1.254 | |
| 0,08471 % | Tema ETFS LLC | 74.269 | 4.575 | |
| 0,08120 % | Manulife Investment Management (North America) Limited | 71.184 | -1.126 | |
| 0,07950 % | NEOS Investment Management, LLC | 69.694 | 13.490 | |
| 0,07761 % | Numeric Investors LLC | 68.043 | 54.232 | |
| 0,07606 % | Millennium Management LLC | 66.686 | -480.951 | |
| 0,07403 % | Fountainhead AM, LLC | 64.901 | 0 | |
| 0,07392 % | State of Wisconsin Investment Board | 64.808 | -5.023 | |
| 0,07364 % | Throne (Jason) | 64.556 | 1.072 | |
| 0,07139 % | Assetmark, Inc. | 62.586 | 12.836 | |